Publications by authors named "Natalia H Hajdamowicz"
Article Synopsis
- Peptidoglycan is essential for the structure and integrity of the Staphylococcus aureus cell wall and is targeted by key antibiotics; however, its behavior during infection is not well understood.
- Researchers developed techniques to extract and analyze bacterial cell walls from active infections, revealing that these cells are smaller and have thicker walls compared to those grown in lab conditions.
- The study found that specific enzymes and proteins, like PBP4 and SagB, significantly influence Staphylococcus aureus's ability to survive and thrive in host environments, highlighting the complexity of peptidoglycan dynamics in disease.
Neutrophils are key to host defence, and impaired neutrophil function predisposes to infection with an array of pathogens, with a common and sometimes life-threatening problem in this setting. Both infiltrating immune cells and replicating bacteria consume oxygen, contributing to the profound tissue hypoxia that characterises sites of infection. Hypoxia in turn has a dramatic effect on both neutrophil bactericidal function and the properties of , including the production of virulence factors.
View Article and Find Full Text PDFAmong opportunistically pathogenic filamentous fungi of the Aspergillus genus, Aspergillus fumigatus stands out as a drastically more prevalent cause of infection than others. Utilizing the zebrafish embryo model, we applied a combination of non-invasive real-time imaging and genetic approaches to compare the infectious development of A. fumigatus with that of the less pathogenic A.
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