Publications by authors named "Natalia Giannakopoulou"

Enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) are gastrointestinal pathogens responsible for severe diarrheal illness. EHEC and EPEC form "attaching and effacing" lesions during colonization and, upon adherence, inject proteins directly into host intestinal cells via the type III secretion system (T3SS). Injected bacterial proteins have a variety of functions but generally alter host cell biology to favor survival and/or replication of the pathogen.

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Background  Patients undergoing hemodialysis face multiple problems such as difficulties in performing daily activities, low functional capacity, non-adherence to the hemodialysis regimen, and depressive symptoms that lead to poor health outcomes. The present study aimed to assess the levels of depression, adherence, and functionality in patients undergoing hemodialysis, as well as the association between the above variables. Materials and methods In this cross-sectional study, 100 patients undergoing hemodialysis from a private hospital in Athens participated.

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The aim of this study was to investigate the effect of patients' knowledge on adherence to the hemodialysis regimen and Quality of Life (QoL) of patients undergoing hemodialysis as well as the effect of adherence on QoL. Also, the effect of demographic and clinical characteristics on the above three variables was studied. In this cross-sectional study conducted between March and May 2017, 321 patients on hemodialysis from six hemodialysis units completed the Kidney Disease Questionnaire, the GR-Simplified Medication Adherence Questionnaire and the Missoula Vitas Quality of Life Index-15 to measure the patient knowledge, the adherence to hemodialysis regimen, and the QoL, respectively.

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Introduction: The international literature presents a significant gap in the study of the factors affecting caring behaviors as perceived by nurses. This gap requires the study of the factors of nurses' caring behavior.

Aim: The translation and the cultural adaptation of the Factors of Nurses Caring Behaviors (FNCB) scale in the Greek language, the validity, and internal consistency of the scale.

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Introduction: Health-related quality of life is a major issue among patients with Multiple sclerosis (MS).

Aim: To explore the effect of fatigue and pain self-efficacy on health-related quality of life among patients with MS.

Methods: Between March and May 2018, 85 MS patients from a large Hospital of Athens region completed the questionnaires: a) Missoula-VITAS Quality of Life Index-15, which examines 5 dimensions of quality of life, b) Pain Self Efficacy Questionnaire which measures the pain self-efficacy that an individual perceives, c) Fatigue Assessment Scale (FAS) which measures fatigue, d) a questionnaire about the sociodemographic elements.

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is a murine pathogen used to model the intestinal infection caused by Enteropathogenic and Enterohemorrhagic (EPEC and EHEC), two diarrheal pathogens responsible for morbidity and mortality in developing and developed countries, respectively. During infection, these bacteria must sense and adapt to the gut environment of the host. In order to adapt to changing environmental cues and modulate expression of specific genes, bacteria can use two-component signal transduction systems (TCS).

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Background: Association between perceived social support and quality of life in hemodialysis patients represents a new area of interest.

Aim: The aim of this study was to explore the effect of social support on the quality of life of hemodialysis patients.

Material And Methods: In this study 258 hemodialysis patients were enrolled.

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Article Synopsis
  • Citrobacter rodentium is studied as a model for intestinal infections similar to those caused by harmful E. coli strains, utilizing TCSs to adapt to the host environment during infection.
  • Researchers identified 26 TCSs in C. rodentium, demonstrating they are all active during murine infections, with some TCS deletions leading to changes in virulence.
  • The study found that specific strains, like ΔarcA and ΔrcsB, showed reduced virulence, while ΔuvrY displayed increased virulence, suggesting a connection between these TCSs and the cell surface characteristics, which could inform future drug development strategies.
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Citrobacter rodentium is a murine intestinal pathogen used as a model for the foodborne human pathogens enterohemorrhagic Escherichia coli and enteropathogenic E. coli. During infection, these pathogens use two-component signal transduction systems to detect and adapt to changing environmental conditions.

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