Cellular and Behavioral Characterization of Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.

Mutations in the X-linked cell adhesion protein PCDH19 lead to seizures, cognitive impairment, and other behavioral comorbidities when present in a mosaic pattern. Neither the molecular mechanisms underpinning this disorder nor the function of PCDH19 itself are well understood. By combining RNA hybridization with immunohistochemistry and analyzing single-cell RNA sequencing datasets, we reveal expression in cortical interneurons and provide a first account of the subtypes of neurons expressing /, both in the mouse and the human cortex.