Publications by authors named "Natalia G Shebardina"
Autoimmune uveitis is a relapsing blind-causing ocular condition with complex pathogenesis that is not completely understood. There is a high demand for accurate animal models of experimental autoimmune uveitis (EAU) suitable for elucidating the molecular mechanisms of the disease and testing new therapeutic approaches. Here, we demonstrated that photoreceptor Ca/Zn-sensor protein recoverin is a uveoretinal antigen in albino rabbits provoking typical autoimmune chorioretinitis 2-4 weeks after immunization.
View Article and Find Full Text PDFPhotodamage to the outer segments of photoreceptor cells and their impaired utilization by retinal pigment epithelium (RPE) cells contribute to the development of age-related macular degeneration (AMD) leading to blindness. Degeneration of photoreceptor cells and RPE cells is triggered by reactive oxygen species (ROS) produced by photochemical reactions involving bisretinoids, by-products of the visual cycle, which accumulate in photoreceptor discs and lipofuscin granules of RPE. Carotenoids, natural antioxidants with high potential efficacy against a wide range of ROS, may protect against the cytotoxic properties of lipofuscin.
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- Primary open-angle glaucoma (POAG) is a common cause of blindness, linked to increased intraocular pressure and damage to the optic nerve and retinal cells, making early detection crucial for preserving vision.
- Traditional diagnosis is challenging due to the disease's asymptomatic nature in its early stages, but recent research indicates that analyzing tear fluid (TF) for protein changes can provide valuable biomarkers.
- A new method using differential scanning fluorimetry (nanoDSF) identified distinct TF protein profiles in 311 patients, allowing for a 70% identification rate of POAG, while machine learning minimized false positives to 13.5%, revealing significant changes in specific proteins and ligands associated with glaucoma.
Malignant melanoma is one of the most aggressive forms of cancer and the leading cause of death from skin tumors. Given the increased incidence of melanoma diagnoses in recent years, it is essential to develop effective treatments to control this disease. In this regard, the use of cancer vaccines to enhance cell-mediated immunity is considered to be one of the most modern immunotherapy options for cancer treatment.
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