Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults.

Background/aim: Cannabis use is highly prevalent in adolescents; however, little is known about its effects on adolescent brain function.

Method: Resting-state functional magnetic resonance imaging was used in matched groups of regular cannabis users ( = 70, 35 adolescents: 16-17 years old, 35 adults: 26-29 years old) and non-regular-using controls ( = 70, 35 adolescents/35 adults). Pre-registered analyses examined the connectivity of seven major cortical and sub-cortical brain networks (default mode network, executive control network (ECN), salience network, hippocampal network and three striatal networks) using seed-based analysis methods with cross-sectional comparisons between user groups and age groups.

The acute effects of cannabis with and without cannabidiol in adults and adolescents: A randomised, double-blind, placebo-controlled, crossover experiment.

Background And Aims: Long-term harms of cannabis may be exacerbated in adolescence, but little is known about the acute effects of cannabis in adolescents. We aimed to (i) compare the acute effects of cannabis in adolescent and adult cannabis users and (ii) determine if cannabidiol (CBD) acutely modulates the effects of delta-9-tetrahydocannabinol (THC).

Design: Randomised, double-blind, placebo-controlled, crossover experiment.

The Effects of Acute Cannabis With and Without Cannabidiol on Neural Reward Anticipation in Adults and Adolescents.

Background: Adolescents may respond differently to cannabis than adults, yet no previous functional magnetic resonance imaging study has examined acute cannabis effects in this age group. In this study, we investigated the neural correlates of reward anticipation after acute exposure to cannabis in adolescents and adults.

Methods: This was a double-blind, placebo-controlled, randomized, crossover experiment.