Publications by authors named "Natalia Espinosa-Ponce"
Article Synopsis
- Amyloid beta peptides (Aβ) are important markers for Alzheimer's disease and are associated with cognitive decline in Parkinson's disease (PD) and other neurodegenerative conditions.
- The study used a 6-Hydroxydopamine (6-OHDA) model in Wistar rats to investigate Aβ accumulation following dopaminergic cell damage induced by the injection.
- Results indicated a significant increase in Aβ levels at the injection site one hour after the 6-OHDA injection, with a notable presence in blood vessels and possible neuronal cells, linking Aβ accumulation to the progression of PD and its cognitive implications.
An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation.
Andrés De Freitas-Suarez Natalia Espinosa-Ponce Natalia Alvarez-Roger Arianna Iris Cabrera-Suarez Guillermo Jiménez-Jordán
Life (Basel)
November 2023
HIV-associated neurocognitive disorders (HANDs) continue to impact patients despite antiretroviral therapy. A combination of antiretroviral therapies can diminish the HIV viral load to near undetectable levels, but fails to preserve neurocognitive integrity. The cytokine leukemia inhibitory factor (LIF) has shown neuroprotective properties that could mitigate neurodegeneration in HANDs.
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