Characterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens.

Candidiasis is an infectious disease caused by some fungi of the genus Candida. In Brazil, the incidence rate is higher than in European countries and the United States, and health problems occur mainly due to the virulence factors of the fungi, which have made treatment with commercial drugs difficult. Considering the context, plants rich in phenolic compounds, such as those of the genus Piper, have been studied due to their antimicrobial properties.

Teaching the history of nursing: an overview of Brazilian public universities.

Objective: To describe the teaching of the History of Nursing in the curricular structures of Undergraduate Nursing Courses at Brazilian public universities.

Method: A documentary, descriptive study with a qualitative approach carried out between February 2021 and August 2023. The sample included the curricula of active face-to-face undergraduate courses at public educational institutions (n=136) identified on the e-MEC platform.

Food service safety and hygiene factors: a longitudinal study on the Brazilian consumer perception.

The objective of this study was to investigate the perceptions and attitudes of consumers toward food service safety and hygiene when purchasing ready-to-eat food. Data were collected at three time points: before (T0) and during the COVID-19 pandemic (T1 and T2). Among the 333 participants, 45.

Anticonvulsant, Anticholinesterase and Cytoprotective Effects of the Aqueous Extract of Cham.

(1) Background: Cham is a Brazilian aromatic plant rich in phenolic compounds. In traditional medicine, its leaves are used to treat diseases of the Central Nervous System such as stress and anxiety. This study evaluates the capacity of the aqueous extract of as an anticonvulsant, anticholinesterase and antihemolytic agent.

Environmental Biofilms from an Urban Community in Salvador, Brazil, Shelter Previously Uncharacterized Saprophytic Leptospira.

Biofilms are complex microecosystems with valuable ecological roles that can shelter a variety of microorganisms. Spirochetes from the genus Leptospira have been observed to form biofilms in vitro, in rural environments, and in the kidneys of reservoir rats. The genus Leptospira is composed of pathogenic and non-pathogenic species, and the description of new species is ongoing due to the advent of whole genome sequencing.

Development of multiplex real-time PCR for detection of clarithromycin resistance genes for the group.

The molecular identification and its drug-resistance profile are important to choose the correct therapy. This work developed a multiplex real-time PCR (mqPCR) for detection of clarithromycin resistance genes for the group. Isolates received by Adolfo Lutz Institute from 2010 to 2012, identified by PCR restriction enzyme analysis of a fragment of the 65 gene (PRA-65) as type 1 (=135) and 2 (=71) were used.

C NMR spectroscopic data of aporphine alkaloids.

This study involves aporphine alkaloids identified through C Nuclear Magnetic Resonance (NMR) spectroscopic data. For the present publication, articles were selected from several databases on aporphine alkaloids from 1994 to 2021. In this class, more than 700 compounds have been registered, with 221 were included in this section, among which 122 were characterized for the first time in the investigated period.

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Lippia sidoides Cham. (Verbenaceae) is a species often mentioned in traditional medicine due to the medicinal properties attributed to its leaves, which include antibacterial, antifungal, acaricidal and antioxidant. Several of these actions have been scientifically proven, according to reports in the literature; however, little is known about toxicological aspects of this plant.

TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals.

HTLV-1-infected individuals may develop a neurologic inflammatory condition known as HTLV-1-associated myelopathy (HAM/TSP), in which the high production of TNF is observed. These patients exhibit higher proviral loads, enhanced production of proinflammatory cytokines and lymphocyte proliferation in comparison to asymptomatic HTLV-1 carriers and those presenting overactive bladder (OAB-HTLV-infected). Metalloproteinases (MMPs) are known to degrade the components of the blood-brain barrier, favoring the migration of infected cells into the central nervous system.

Chemical Composition and Antimicrobial Potential of Essential Oil of (Gardner) R.M.King & H.Rob. (Asteraceae).

Microbial resistance has become a worrying problem in recent decades after the abusive use of antibiotics causing the selection of resistant microorganisms. In order to circumvent such resistance, researchers have invested efforts in the search for promising natural substances, such as essential oils. Thus, the objective of this work was to determine the chemical composition of the essential oil of leaves, to evaluate its intrinsic effect and its effects in combination with drugs against pathogenic fungi and bacteria, in addition to verifying the inhibition of virulence in strains.

Utilization of Agro-Industrial Residues in the Rearing and Nutritional Enrichment of Larvae: New Food Raw Materials.

Edible insects are a potential alternative food source of high feed conversion efficiency and protein content. is an edible insect that adapts to different diets, enabling sustainable rearing by adding value to by-products and agro-industrial residues. This study aimed to evaluate the performance and nutritional characterization of larvae fed with different proportions of grape residue.

Analysis and Modeling of Innovations in the Global Microalgae Lipids Market.

Microalgae lipids offer numerous advantages over those of plants and animals, enabling the sustainable commercialization of high value-added products in different markets. Although these markets are in a vertiginous annual expansion, technological life cycle modeling is a tool that has been rarely used for microalgae. Life cycle modeling is capable of assisting with decision-making based on data and is considered as a versatile model, usable in multiple software analyzing and diagnostic tasks.

Chemical Profile and Evaluation of the Antioxidant and Anti-Acetylcholinesterase Activities of L. (Annonaceae) Extracts.

This study presents the chemical profile of extracts from the pulp and seed of L., as well as the evaluation of their antioxidant and acetylcholinesterase inhibition activities. In the chemical prospection, qualitative assays were performed, and the contents of total phenols, flavonoids, vitamin C, and carotenoids were quantified.

Home food insecurity during the suspension of classes in Brazilian public schools due to the COVID-19 pandemic.

Objectives: We sought to evaluate the effect of socioeconomic conditions and variables related to the COVID-19 pandemic on the food insecurity of students during suspension of classes in public schools.

Methods: This was a telephone survey (n = 612) of adults responsible for purchasing food through representative samples of students in two Brazilian municipalities in June and July 2020. The outcome was food insecurity, assessed using the Brazilian Food Insecurity Scale.

Patient-centered outcomes in non-small-cell lung cancer: a real-world perspective.

To assess non-small-cell lung cancer (NSCLC) patient-centered outcomes in the real world. This is a prospective study of NSCLC patients treated at a private cancer care institution in Brazil between 2014 and 2019. The report comprises 337 patients.

Quasinormal-Mode Perturbation Theory for Dissipative and Dispersive Optomechanics.

Despite the several novel features arising from the dissipative optomechanical coupling, such effect remains vastly unexplored due to the lack of a simple formalism that captures non-Hermiticity in the engineering of optomechanical systems. In this Letter, we show that quasinormal-mode-based perturbation theory is capable of correctly predicting both dispersive and dissipative optomechanical couplings. We validate our model through simulations and also by comparison with experimental results reported in the literature.

Histological response and expression of collagen, metalloproteinases MMP-1 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 in fetal membranes following open intrauterine surgery: an experimental study.

Objective: To characterize aspects of the repair process by evaluating the tissue collagen density, metalloproteinases and tissue inhibitor of matrix metalloproteinases in the fetal membranes following open fetal surgery for myelomeningocele (MMC).

Design: Experimental.

Setting: Two Brazilian hospitals in 2013-2014.

Transposable DNA Elements in Amazonian Fish: From Genome Enlargement to Genetic Adaptation to Stressful Environments.

Transposable elements have driven genome evolution and plasticity in many ways across a range of organisms. Different types of biotic and abiotic stresses can stimulate the expression or transposition of these mobile elements. Here, we cytogenetically analyzed natural fish populations of the same species living under different environmental conditions to test the influence and organization of transposable elements in their genome.

Annona Genus: Traditional Uses, Phytochemistry and Biological Activities.

Species from the Annona (Anonaceae) genus are used in traditional medicine for the treatment of various diseases. Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as in vitro, in vivo, and clinical tests can provide evidence supporting ethnopharmacological reports, directing studies towards the isolation of compounds which may be active for specific pathologies. Annona muricata and Annona squamosa were the most commonly reported species from those studied, with Annona cherimola and Annona classiflora also standing out.

Investigation of chromosomal alterations in patients with Alzheimer's disease in the state of Amazonas, Brazil.

Objectives: Alzheimer's disease (AD) has as its main characteristic the deterioration of cerebral functions. Its etiology is still complex and undefined despite the progress made in understanding its neurological, infectious, biochemical, genetic and cytogenetic mechanisms.

Methods: Considering this, the aim of this study was to investigate the presence of chromosomal alterations in the peripheral blood lymphocytes, and to verify if there was a high frequency of these alterations in patients diagnosed with AD at the University Hospital GetúLio Vargas Outpatient Clinic Araújo Lima in Manaus, Amazonas, Brazil.

Correlation between nutritional assessment and oxidative stress in candidates for liver transplant.

Objective: To evaluate the oxidative profile, nutritional status and food intake (caloric value; macronutrients; vitamins A, E and C; and zinc), and to correlate oxidative stress with nutritional status in patients who were candidates for liver transplant.

Methods: This is a cross-sectional, analytical, and descriptive study with 51 candidates for liver transplant. Sociodemographic and clinical data, anthropometric parameters, food consumption, and a 10mL blood sample were collected from each patient.

Antibiotic-Potentiating Activity of Phanostenine Isolated from Cissampelos sympodialis Eichler.

Cissampelos sympodialis Eichler is well studied and investigated for its antiasthmatic properties, but there are no data in the literature describing antibacterial properties of alkaloids isolated from this botanical species. This work reports the isolation and characterization of phanostenine obtained from roots of C. sympodialis and describes for the first time its antimicrobial and antibiotic modulatory properties.

The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers.

The cytotoxic activities of CD8 T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1). As with CD8 T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes. NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection.

Complexation of whey protein with caffeic acid or (-)-epigallocatechin-3-gallate as a strategy to induce oral tolerance to whey allergenic proteins.

Proteins and phenolic compounds can interact and form soluble and insoluble complexes. In this study, the complexation of whey protein isolate (WPI) with caffeic acid (CA) or (-)‑epigallocatechin‑3‑gallate (EGCG) is investigated as a strategy to attenuate oral sensitization in C3H/HeJ mice against WPI. Treatment with WPI-CA reduced the levels of IgE, IgG1, IgG2a and mMCP-1 in serum of mice measured by ELISA.