Identification and Quantification by NMR Spectroscopy of the 22 and 22 Epimers in Budesonide Pharmaceutical Forms.

The authors developed four variants of the qNMR technique (H or C nucleus, DMSO-d6 or CDCl solvent) for identification and quantification by NMR of 22 and 22 epimers in budesonide active pharmaceutical ingredient and budesonide drugs (sprays, capsules, tablets). The choice of the qNMR technique version depends on the drug excipients. The correlation of H and C spectra signals to molecules of different budesonide epimers was carried out on the basis of a comprehensive analysis of experimental spectral NMR data (H-H gCOSY, H-C gHSQC, H-C gHMBC, H-H ROESY).

Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan.

Objective: Study of embryotoxicity, teratogenicity and reproductive toxicity of the new drug Lipophtalocyan in rats.

Material And Methods: Studies were conducted on 210 non-inbred female rats and 105 non-inbred male rats. The drug was administered daily via i.

The Development of a Parenteral Pharmaceutical Formulation of a New Class of Compounds of Nitrosourea.

Despite the rapid development of medical technologies, chemotherapy treatment still occupies an important place in clinical oncology. In this regard, the current research in this area focuses on the synthesis of new highly effective antitumor substances that have minimal side effects and the development of stable pharmaceutical formulations (PF) on their basis. In order to solve this problem, the I.