Publications by authors named "Natalia Barraza"
In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as altered neuronal function in DS.
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- Dynamin has been linked to regulating the amount and type of neurotransmitters released during exocytosis, but its mechanism is still not well understood.
- Research using bovine adrenal chromaffin cells showed that inhibiting dynamin affects the formation and structure of the actin cytoskeleton, which is crucial for exocytosis.
- The findings suggest that dynamin-2 works with F-actin to control the late stages of exocytosis, ultimately influencing hormone release to meet physiological needs.
Neurodegenerative disorders constitute a growing concern worldwide. Their incidence has increased steadily, in particular among the elderly, a high-risk population that is becoming an important segment of society. Neurodegenerative mechanisms underlie many ailments such as Parkinson's disease, Huntington's disease, Alzheimer's disease (AD) and Down syndrome (DS, trisomy 21).
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