Publications by authors named "Natalia Asimakopoulou"
Article Synopsis
- The study investigates the role of the HER2 P95 isoform in patients with metastatic breast cancer who are treated with trastuzumab, focusing on its impact on treatment resistance.
- A retrospective analysis of 114 patients revealed that higher P95 expression is linked to increased HER2 copy number variations and other aggressive cancer markers, suggesting a potential mechanism of resistance.
- The findings indicate that patients with HER2-negative but high P95 expression may face a higher risk of death, highlighting the importance of P95 in understanding treatment outcomes.
Background: Although colorectal cancer (CRC) is a disease of the older patients, older patients are under-represented from randomized trials. Herein we conducted a retrospective analysis for the effect of panitumumab in the management of older patients (≥65 years) patients with metastatic CRC (mCRC) in the Hellenic Oncology Research Group's (HORG) database.
Methods: Τhe efficacy of panitumumab-based chemotherapy as front-line treatment in older patients with mCRC was assessed.
Article Synopsis
- - The study aimed to evaluate anticoagulation therapy (AT) in elderly patients with atrial fibrillation (AF) and how frailty status impacts their long-term treatment outcomes.
- - Conducted in Greece with 104 patients aged 75 and older, the study found that 78.8% received AT at discharge; those not given AT had higher frailty and bleeding risk scores.
- - Over one year, the follow-up showed high mortality rates (57.6% of patients) and substantial hospital readmissions (62.5%), emphasizing the need for better management of anticoagulation in frail elderly patients.
Introduction: Acute cholecystitis and biliary colic may have signs and symptoms similar to those of Acute Coronary Syndrome(ACS) along with ischemic ECG changes. Cholecystitis and/or biliary colic have been both reported as trigger factors for bradyarrhythmia in the literature.
Case Report: A 78-year-old male patient was admitted to our Emergency Department (ED) due to acute abdominal pain.
Despite the high prevalence of colorectal cancer in a continuously aging population and the substantial advances in the treatment of metastatic disease during the past decade, the treatment of elderly patients with advanced, unresectable or metastatic colorectal cancer is a clearly unmet need. Since older patients are under-represented or even excluded from randomized trials, the evidence that oncologists use as guidance is weak. However, small prospective studies, pooled analyses and observational studies show that combination approaches are safe, efficacious and feasible in the geriatric population with metastatic colorectal cancer.
View Article and Find Full Text PDFContext: Gangliocytic paraganglioma is a rare tumor, almost always located in the second portion of the duodenum, and manifested with upper gastrointestinal bleeding and abdominal pain. To date, only one case of duodenal gangliocytic paraganglioma presented with recurrent acute pancreatitis has been reported in the literature.
Case Report: We present a 72-year-old woman admitted to the hospital due to recurrent episodes of acute pancreatitis.