Publications by authors named "Natalia Andreychuk"
Background: The familial hypercholesterolemia (FH) diagnosis is based on clinical and genetic criteria. A relevant proportion of FH patients fulfilling the criteria for definite FH have negative genetic testing. Increasing the identification of true genetic-based FH is a clinical challenge.
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- Both Nordic and Mediterranean diets have been recognized as healthy, but their effects on children with familial hypercholesterolemia (FH) and their lipoprotein profiles are not well understood.
- In a study involving 256 children, researchers compared the lipoprotein profiles of those with heterozygous FH from Spain and Norway, finding notable differences in LDL and HDL particle sizes and numbers between the two groups.
- The results indicated that while overall lipid levels were similar between the two dietary groups, specific dietary fats in Norwegian children correlated with variations in their lipoprotein profiles, highlighting the role of diet in managing FH.
Statins have contributed to the prevention of numerous atherosclerotic cardiovascular (CV) events and cardiovascular deaths in the past three decades. The benefit of statins is mainly mediated by the lowering of LDLc. According to scientific evidence, the current international guidelines recommend very low LDLc goals in patients at high/very high cardiovascular risk because they are associated with fewer CV events and improvements in atherosclerotic plaques.
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- Hypertension is linked to low-grade inflammation, with glycoproteins A, B, and F being potential indicators of this inflammatory state in affected patients.
- A study involving 340 patients (211 hypertensive and 129 normotensive) found that hypertensive individuals had higher levels of these glycoproteins, which correlated with increased blood pressure and prevalence of conditions like obesity and diabetes.
- The research suggests that elevated glycoproteins A, B, and F contribute to systemic inflammation, potentially leading to vascular injury and damage in other organs among hypertensive patients.
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- * In the second wave, patients tended to be younger, with shorter hospital stays and lower fatality rates; there was an increase in the number of children and pregnant women needing hospitalization.
- * Common symptoms in both waves included fever and cough, but the second wave also saw a rise in renal and gastrointestinal issues, and differences in treatment approaches and mortality risk factors were identified, indicating a shift in the virus's impact over time.