Publications by authors named "Natali Nakic"
Prion diseases are a group of neurodegenerative diseases affecting a wide range of mammalian species, including humans. During the course of the disease, the abnormally folded scrapie prion protein (PrPSc) accumulates in the central nervous system where it causes neurodegeneration. In prion disorders, the diverse spectrum of illnesses exists because of the presence of different isoforms of PrPSc where they occupy distinct conformational states called strains.
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- Immunoglobulin G (IgG) is the main type of antibody in the blood, with its structure and function influenced by sugar molecules called glycans, which vary with age and disease.
- This study examined IgG glycosylation patterns across 5 populations, totaling over 10,000 samples, revealing that many glycan features are linked to country of residence, particularly monogalactosylation.
- An association was found between low levels of galactosylation in individuals from developing countries and factors like inflammation and biological age, highlighting how environmental influences may impact health in these regions.
Immunoglobulin G (IgG) glycans are emerging as a new putative biomarker for biological age and different diseases, requiring a robust workflow for IgG glycome analysis, ideally beginning with a simple and undemanding sampling procedure. Here, we report the first comprehensive study on total N-glycans of IgG isolated from dried blood spots (DBSs), which was performed in a high-throughput mode. We compared the IgG N-glycan profiles originating from DBS with those originating from plasma, compared different media for DBS collection, evaluated analytical variation and assessed IgG N-glycan profile stability for different storage conditions.
View Article and Find Full Text PDFBackground: Statins are among the most widely prescribed medications worldwide and usually many individuals involved in clinical and population studies are on statin therapy. Immunoglobulin G (IgG) glycosylation has been associated with numerous cardiometabolic risk factors.
Methods: The aim of this study was to investigate the possible association of statin use with N-glycosylation of IgG.