Publications by authors named "Natali Barakat"
Article Synopsis
- The study investigates the link between amyloid-β (Aβ) and cognitive decline in Alzheimer's disease (AD) by analyzing how Aβ affects cortical neuronal function and promotes cellular aging.
- Researchers used human-derived cortical neurons to measure long-term potentiation (LTP) and found that Aβ reduced LTP and increased senescence, along with the release of inflammatory factors associated with AD.
- The findings suggest a novel model for understanding AD pathology, indicating that while therapeutic molecules can improve neuronal function, they do not stop Aβ-induced aging, highlighting the need for better treatments.
In vitro culture longevity has long been a concern for disease modeling and drug testing when using contractable cells. The dynamic nature of certain cells, such as skeletal muscle, contributes to cell surface release, which limits the system's ability to conduct long-term studies. This study hypothesized that regulating the extracellular matrix (ECM) dynamics should be able to prolong cell attachment on a culture surface.
View Article and Find Full Text PDFBackground: According to the World Health Organization (WHO), pneumonia is the leading infectious cause of death in children below 5 years old. Hence, the early detection of pediatric pneumonia is crucial to reduce its morbidity and mortality rates. Even though chest radiography is the most commonly employed modality for pneumonia detection, recent studies highlight the existence of poor interobserver agreement in the chest X-ray interpretation of healthcare practitioners when it comes to diagnosing pediatric pneumonia.
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