Effect of Cooling Capsaicin Application Site on Reducing Burning Sensation in Neuropathic Pain Patients: A Randomized Controlled Trial.

Purpose: Treatment of localized neuropathic pain continues to represent an unmet need. The primary objective of the present study was to evaluate the efficacy of cryotherapy to reduce the burning pain induced by capsaicin (8%) patches (QUTENZA) in a neuropathic pain cohort. We also investigated subsequent neuropathic pain during an 8-week follow-up.