Publications by authors named "Natacha Leon-Alvarez"
Background: Poststroke fatigue is a prevalent issue among stroke survivors, significantly impeding functional recovery and diminishing their quality of life.
Aim: This prospective cohort study aims to investigate the association between poststroke fatigue and the extent of functional recovery in survivors of ischemic and hemorrhagic strokes. Additionally, it seeks to delineate the temporal progression of poststroke fatigue in these two stroke subtypes.
Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury.
Spinal Cord
August 2024
Article Synopsis
- Double-blind, randomized, placebo-controlled phase IIA trial tested the safety and pain relief efficacy of NFX-88 in chronic spinal cord injury (SCI) patients.
- A total of 61 adults with varying levels of SCI participated, receiving either a placebo or one of three NFX-88 doses alongside pregabalin.
- Results showed no severe side effects and indicated that the 2.1g/day dose of NFX-88 provided the most significant reduction in neuropathic pain, suggesting its potential for future trials.
The purpose of this document is to establish practical recommendations on neurogenic bladder (NB) management based on scientific evidence and medical and nursing perspective in Spinal Cord Injury (SCI) Units as a first multidisciplinary consensual approach in Spain. METHODS: This paper reports results from the first modified Delphi consensus building exercise on this procedure. A committee of recognised opinion-leaders in rehabilitation and urology with special interest in NB was constituted.
View Article and Find Full Text PDFAim: To evaluate the potential reorganization of the sensorimotor cortex in a patient with traumatic brain injury after an intensive motor rehabilitation.
Patients And Methods: A 17-year-old male with severe traumatic brain injury was submitted to functional magnetic resonance imaging (fMRI) analyses of motor control before and after motor rehabilitation. The motor tasks performed during fMRI were finger tapping, ankle plantar flexion, and toe flexion.