Publications by authors named "Natacha Buergin"
Aims: To explore the incidence and potential mechanisms of oligosymptomatic myocardial injury following COVID-19 mRNA booster vaccination.
Methods And Results: Hospital employees scheduled to undergo mRNA-1273 booster vaccination were assessed for mRNA-1273 vaccination-associated myocardial injury, defined as acute dynamic increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration above the sex-specific upper limit of normal on day 3 (48-96 h) after vaccination without evidence of an alternative cause. To explore possible mechanisms, antibodies against interleukin-1 receptor antagonist (IL-1RA), the SARS-CoV-2-nucleoprotein (NP) and -spike (S1) proteins and an array of 14 inflammatory cytokines were quantified.
Article Synopsis
- * In a cohort of 8,618 patients, significant risk reclassification occurred, with sensitivity for identifying myocardial infarctions (MIs) varying widely across GRACE scores, showing a maximum sensitivity of only 66.5% compared to 78.1% for the ESC 0/1 h-algorithm.
- * While combining GRACE scoring with hs-cTn testing slightly boosts MI detection, it also raises the likelihood of false positives, potentially leading to unwarranted