A Comparison of Adhesion to Metal and Ceramic Brackets with Coated and Uncoated Nickel Titanium Orthodontic Archwires: An In Vitro Study.

Background And Objective: According to microbiological investigations, microorganisms, especially Lactobacillus strains, considerably increase after using fixed orthodontic appliances. One of the Lactobacilli bacteria found in the oral cavity is . The purpose of this study was to compare the adhesion of to metal and ceramic brackets with coated and uncoated nickel titanium (NiTi) orthodontic archwires.

Specific delivery of metronidazole using microparticles and thermosensitive hydrogel for intrapocket administration as an alternative in periodontitis treatment.

Periodontitis is a common chronic inflammatory disease primarily caused by the prevalence of bacterial overgrowth resulting in the development of an inflammatory condition that destroys the tooth's supporting tissues and eventual tooth loss. Comparatively, to other treatment methods, it is difficult for topical antibacterial drugs to effectively permeate the biofilm's physical barrier, making conventional therapy for periodontitis more challenging. This novel study combines thermosensitive hydrogel with microparticles (MPs) to enhance the targeted delivery of metronidazole (MET) to the periodontal pocket.