Absolute choline tissue concentration mapping for prostate cancer localization and characterization using 3D H MRSI without water-signal suppression.

Purpose: Until now, H MRSI of the prostate has been performed with suppression of the large water signal to avoid distortions of metabolite signals. However, this signal can be used for absolute quantification and spectral corrections. We investigated the feasibility of water-unsuppressed MRSI in patients with prostate cancer for water signal-mediated spectral quality improvement and determination of absolute tissue levels of choline.

Simple and broadly applicable automatic quality control for 3D H MR spectroscopic imaging data of the prostate.

Purpose: Quality control (QC) is a prerequisite for clinical MR spectroscopic imaging (MRSI) to avoid that bad spectra hamper data interpretation. The aim of this work was to present a simple automatic QC for prostate H MRSI that can handle data obtained with different commonly used pulse sequences, echo times, field strengths, and MR platforms.

Methods: A QC method was developed with a ratio (Qratio) where the numerator and the denominator are functions of several signal heights, logically combined for their positive or negative contribution to spectral quality.

Simultaneous F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer.

To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and F-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. In a cohort of 19 high-risk prostate cancer patients that underwent simultaneous PET/MRI, we evaluated the diagnostic performance of MRSI and PET for discrimination of aggressive cancer lesions from healthy tissue and benign lesions. Data analysis comprised calculations of correlations of mean standardized uptake values (SUV), maximum SUV (SUV), and the MRSI-derived ratio of (total choline + spermine + creatine) to citrate (CSC/C).

High-Quality 3-Dimensional 1H Magnetic Resonance Spectroscopic Imaging of the Prostate Without Endorectal Receive Coil Using A Semi-LASER Sequence.

Objectives: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements.

Materials And Methods: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil.

In vivo MR spectroscopic imaging of the prostate, from application to interpretation.

Proton magnetic resonance spectroscopic imaging (H MRSI) enables non-invasive assessment of certain metabolites in the prostate gland. Several studies have demonstrated that this metabolic information, in combination with anatomical information from T2-weighted MR imaging significantly improves prostate cancer detection, localization and disease characterization. The technology of H MRSI is continuously evolving with improvements of hardware and acquisition methods.