Publications by authors named "Nassiba Menghoum"
Objectives: The debate over extending the legal time limit for abortion in Belgium has intensified in recent years. Health care providers must refer patients seeking abortion beyond the legal deadline to other countries, such as the Netherlands, where the time limits are more permissive. In light of this situation, we analyzed the demographic and social characteristics of patients requesting abortion after 14 weeks of gestation and compared them with those seeking the procedure within the legal limits.
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- Myo-inositol is elevated in patients with heart failure (HF), particularly in those with heart failure with preserved ejection fraction (HFpEF), and is associated with negative clinical outcomes.
- The study measured plasmatic myo-inositol levels in large cohorts from Belgium and Canada, revealing significant increases in HF patients compared to those without.
- Elevated myo-inositol levels correlate with worsening kidney function and cardiac markers, suggesting a potential role in the development and progression of HFpEF.
Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrate antigen 125 (CA 125) has been shown to be a potential marker of congestion and prognosis in HF. We sought to better characterize HFpEF patients with high CA 125 levels by using a multimodal approach.
View Article and Find Full Text PDFPlatelet inhibition is the main treatment strategy to prevent atherothrombotic complications after acute coronary syndrome or percutaneous coronary intervention. Despite dual antiplatelet therapy (DAPT) combining aspirin and a P2Y receptor inhibitor, high on-treatment platelet reactivity (HPR) persists in some patients due to poor response to treatment and is associated with ischemic risk. Tubulin acetylation has been pointed out as a hallmark of stable microtubules responsible for the discoid shape of resting platelets.
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- Heart failure with preserved ejection fraction (HFpEF) has a high association with comorbidities that increase mean platelet volume (MPV), which affects morbidity and mortality in heart failure.
- In a study with 228 HFpEF patients, it was found that patients had significantly higher MPV levels compared to healthy controls, indicating potential clinical relevance.
- Elevated MPV was identified as a strong predictor of adverse outcomes—such as all-cause mortality and hospitalizations—over a median follow-up of 26 months, suggesting its value as a prognostic marker in HFpEF.
Background: Inflammation and oxidative stress are thought to play an important role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) through the development of endothelial dysfunction. Myeloperoxidase (MPO) functions as a link between oxidative stress and inflammation and is an interesting therapeutic target. The objective of this observational cohort study was to compare MPO levels between HFpEF and old controls, to define clinical characteristics associated with high levels of MPO and to assess the relation between MPO levels and vascular function.
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