Publications by authors named "Nasser M Al-Rajhi"
Objective/background: To evaluate the efficacy and outcome of adding low-dose fractionated radiotherapy (LDFRT) to induction chemotherapy plus concurrent chemoradiation in locally advanced nasopharyngeal carcinoma (LANPC).
Methods: A single-institute, phase II-III, prospectively controlled randomized clinical trial was performed at King Faisal Specialist Hospital and Research Centre. Patients aged 18-70 years with WHO type II and III, stage III-IVB nasopharyngeal carcinoma, Eastern Cooperative Oncology Group performance score of 0-2, with adequate hematological, renal, and hepatic function were eligible.
Article Synopsis
- The study investigates how mitochondrial DNA (mtDNA) genetic variations affect patients' responses to radiotherapy, particularly in the development of tissue fibrosis after treatment.* -
- In a group of 32 nasopharyngeal carcinoma patients, researchers found that those who were more sensitive to radiation had a higher number of nonsynonymous genetic variations and a specific variation (A10398G) linked to increased fibrosis risk.* -
- The results suggest that mtDNA variations play a significant role in radiation sensitivity and that these genetic factors should be considered alongside nuclear DNA variations when predicting patient responses to radiotherapy.*
Background: It has been hypothesized that patient to patient variation in normal tissue reactions to radiotherapy is associated with the presence of polymorphic variations in genes involved in DNA repair.
Purpose: To test for a possible association between two single-nucleotide polymorphisms (SNPs), XRCC1 399 G>A Arg/Gln and XRCC3 241 C>T Thr/Met and late reactions to radiotherapy.
Patients And Methods: In this case control study, 50 Head and Neck cancer patients were retrospectively recruited.
Objective: To assess natural history, treatment outcome and pattern of relapse in patients with maxillary sinus carcinoma.
Methods: A review was conducted of the medical records of all adult patients with maxillary sinus carcinoma, who were treated at King Faisal Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia, between January 1990 and December 1999. A total of 60 patients were identified for analysis, 36 men and 24 women; the median age was 58-years (range 23-95).
Objective: To evaluate elective neck treatment in patients with early stage (T1-2 negative neck node [N0]) squamous cell carcinoma of the oral tongue.
Methods: The medical records of all patients with early stage (T1-2 N0) of oral tongue cancer at the King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia, between January 1980 and December 1997, were identified and retrospectively reviewed.
Results: Our cohort consisted of 93 patients: 45 males and 48 females, with a median age of 60 years.