Daily participation in preterm-born children: An exploratory and comparative study.

Background: Preterm birth, particularly with lower gestational age and respiratory complications, can impact neurodevelopmental outcomes and participation in daily activities. Understanding how these children engage in everyday tasks, particularly from the perspective of their parents, is critical for assessing long-term health outcomes and quality of life.

Objectives: This study aims to assess parental perceptions of participation and daily performance in children born preterm, comparing early preterm infants with and without chronic lung disease, late preterms, and term-born children.

Genetic association between Class II division 1 and division 2 malocclusions with PAX9 (rs8004560) gene polymorphism in a tertiary care hospital.

Objective: To assess whether there is any difference in the genetic association between Class II division 1 (div. 1) and division 2 (div. 2) malocclusions using PAX9 (rs8004560) gene single nucleotide polymorphism (SNP).

Copy Number Variants in 30 Saudi Pediatric Patients with Neurodevelopmental Disorders: From Unknown Significance to Diagnosis.

Background: Structural variants (SVs), such as copy number variants (CNVs), insertions, deletions, inversions, and translocations, contribute significantly to genetic diversity and disease etiology. CNVs, which involve the duplication or deletion of DNA segments, are particularly impactful on genes crucial for biological functions and disease processes.

Objective: To reassess unclassified SVs that may be underlying unresolved neurodevelopmental disorders among Saudi patients.

SHH Signaling as a Key Player in Endometrial Cancer: Unveiling the Correlation with Good Prognosis, Low Proliferation, and Anti-Tumor Immune Milieu.

Endometrial Cancer (EC) is one of the most common gynecological malignancies. Despite its prevalence, molecular pathways, such as the Sonic Hedgehog (SHH) pathway, have not been extensively studied in the context of EC. This study aims to explore the clinical implications of SHH expression in EC, potentially uncovering new insights into the disease's pathogenesis and offering valuable insights for therapeutic strategies in EC.

A cross-sectional study on clinical characteristics and severity of children with COVID-19 admitted to a teaching institute in North India.

Background: SARS-CoV-2 infection presentation in children is usually milder than in adults but can be severe and fatal as well. Data on the pediatric population regarding severity and clinical presentation are still limited, and there is a need to have a better understanding of clinical features, severity, and laboratory parameters.

Aims And Objective: To document clinical and laboratory characteristics and outcomes of children with SARS-CoV-2 in a low-middle-income country and to evaluate clinicodemographic factors and biochemical markers associated with severity and mortality.

Predictors and Outcomes Associated with Bariatric Robotic Delivery: An MBSAQIP Analysis of 318,151 Patients.

: The adoption of robotic bariatric surgery has increased dramatically over the last decade. While outcomes comparing bariatric and laparoscopic approaches are debated, little is known about patient factors responsible for the growing delivery of robotic surgery. A better understanding of these factors will help guide the planning of bariatric delivery and resource allocation.

Mg/S@g-CN nanosheets: A promising fluorescence sensor for selective Cu detection in water.

This work describes the development of a novel fluorescence sensor based on magnesium/S@g-CN nanosheets for selective detection of copper (Cu) ions in water. Mg/S@g-CN nanosheets were prepared by the polycondensation technique and investigated by X-ray diffraction (XRD), ATR-FTIR spectroscopy, scanning electron microscopy (SEM), surface area (BET), and UV-Vis optical absorption measurements. XRD and ATR-FTIR analysis showed the characteristic peaks for S@g-CN.

Structure-Property Relationships in PVDF/SrTiO/CNT Nanocomposites for Optoelectronic and Solar Cell Applications.

The optical properties of polyvinylidene fluoride (PVDF) polymer nanocomposite films incorporating SrTiO/carbon nanotubes (CNTs) as nanofillers are investigated. PVDF/SrTiO/CNTs films were prepared by the solution casting technique. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) analyses confirmed the incorporation of SrTiO/CNTs into the PVDF matrix.

Correlation Between Obesity and Mental Health Status in Riyadh, Saudi Arabia.

Introduction: Recent studies show an increase in the incidence and prevalence of obesity worldwide. In Saudi Arabia, the prevalence of obesity, according to the latest studies, was estimated to be 24.7%.

Conflict of interest disclosure by US cardiothoracic surgeons.

Background: Surgeon-industry collaboration is a key driver of advancement in surgical technology and practice. Disclosures of financial relationships between investigators and industries are important to ensure transparent and critical evaluation of literature.

Methods: All American cardiothoracic (CT) surgeons who published in three major CT surgery journals in 2019 were identified.

Quality of life in children with Down syndrome and its association with parent and child demographic characteristics: Parent-reported measures.

Background: This study aims to explore the association between the quality of life (QoL) in children with Down syndrome (DS) and its relationship with demographic characteristics of both parents and children. The investigation encompasses five domains: physical and psychological well-being, autonomy and parental relationship, social well-being, and peers, as well as school and the learning environment.

Method: An online questionnaire, the KIDSCREEN-27, was used to measure the QoL of 112 families with DS in Saudi Arabia, referred to as "Parent-Reported Measures.

Fear of anesthesia for cesarean section among pregnant women: a multicenter cross-sectional study.

Background: Fear of anesthesia for cesarean section delivery is an important health issue that should be addressed by anesthesiologists, obstetricians, and other providers of antenatal and perioperative healthcare. This multicenter study was conducted to assess the fear of anesthesia for cesarean section among Palestinian pregnant women and to identify the predictors of high fear.

Methods: The study was conducted in a cross-sectional design among Palestinian pregnant women in different antenatal healthcare clinics.

A hybrid mesoporous composite of SnO and MgO for adsorption and photocatalytic degradation of anionic dye from a real industrial effluent water.

Water pollution by synthetic anionic dyes is one of the most critical ecological concerns and challenges. Therefore, there is an urgent need to find an efficient adsorbent and photocatalyst for dye removal. In the present study, we aimed to fabricate a hybrid mesoporous composite of spongy sphere-like SnO and three-dimensional (3D) cubic-like MgO (SnO/MgO) as a promising adsorbent/photocatalyst to remove the anionic sunset yellow (SSY) dye from real wastewater at neutral pH conditions.

The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.

Oxford Nanopore sequencing technology (ONT) is currently widely used due to its affordability, simplicity, and reliability. Despite the advantage ONT has over next-generation sequencing in detecting resistance genes in mobile genetic elements, its relatively high error rate (10-15%) is still a deterrent. Several bioinformatic tools are freely available for raw data processing and obtaining complete and more accurate genome assemblies.

Evaluation of the Impact of Two Thiadiazole Derivatives on the Dissolution Behavior of Mild Steel in Acidic Environments.

In light of the variety of industrial uses and economic relevance of mild steel, corrosion resistance is a serious topic. Utilization of inhibitors serves as one of the most essential methods for corrosion control. Two thiadiazole compounds, namely, 2-amino-5-(4-bromobenzyl)-1,3,4-thiadiazole () and 2-amino-5-(3-nitrophenyl)-1,3,4-thiadiazole (), were synthesized.

Genotype-protein phenotype characterization of and missense variants associated with inflammatory bowel disease: A paradigm from molecular modelling, dynamics, and docking simulations.

Inflammatory bowel disease (IBD) is a gastrointestinal disease with an underlying contribution of genetic, microbial, environment, immunity factors. The coding region risk markers identified by IBD genome wide association studies have not been well characterized at protein phenotype level. Therefore, this study is conducted to characterize the role of (Arg675Trp and Gly908Arg) and (Gly149Arg and Arg381Gln) missense variants on the structural and functional features of corresponding proteins.

Heavy metals biosensor based on defective one-dimensional phononic crystals.

In recent years, the detection of water pollution with low levels of heavy metals has attracted the great attention of many researchers as a result of the imminent danger of this type of pollution to all mankind. Meanwhile, we introduce a theoretical approach based on the one-dimensional phononic crystals (1D-PnCs) with a central defect layer as a novel platform for the highly sensitive detection of heavy metal pollution in freshwater. Therefore, the creation of a resonant peak in the transmittance spectrum related to this defect layer is highly conceivable.

Bioinformatics insights into the genes and pathways on severe COVID-19 pathology in patients with comorbidities.

Coronavirus disease (COVID-19) infection is known for its severe clinical pathogenesis among individuals with pre-existing comorbidities. However, the molecular basis of this observation remains elusive. Thus, this study aimed to map key genes and pathway alterations in patients with COVID-19 and comorbidities using robust systems biology approaches.

Family Quality of Life in Children with Severe or Profound Disability: Home Versus Residential Care.

Background: Most children with severe and profound intellectual disability (SPID) are cared for in their homes, according to current recommendations. Yet, their families face marked emotional, health, and economic challenges.

Aims: The aim of this study was to examine family quality of life (FQOL) along with psychological and health factors among families who raise children with SPID at home versus those residing in residential care.

Reviewing the past to inform the future: an 8-year review of severe maternal morbidity.

Background: Maternal morbidity is becoming a key indicator used to compare health systems in the developed world and also to inform clinical practice.

Objective: This study aimed to evaluate a single center experience of severe maternal morbidity over an 8-year period.

Study Design: We conducted a retrospective review of all cases of severe maternal morbidity from 2012 to 2019 at a tertiary level maternity hospital in the Republic of Ireland with approximately 9000 births per year.

A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers.

Prostate cancer (PC) is a fatally aggressive urogenital cancer killing millions of men, globally. Thus, this study aims to identify key miRNAs, target genes, and drug targets associated with prostate cancer metastasis. The miRNA and mRNA expression datasets of 148 prostate tissue biopsies (39 tumours and 109 normal tissues), were analysed by differential gene expression analysis, protein interactome mapping, biological pathway analysis, miRNA-mRNA networking, drug target analysis, and survival curve analysis.

Identification of miRNA-mRNA-TFs regulatory network and crucial pathways involved in asthma through advanced systems biology approaches.

Asthma is a life-threatening and chronic inflammatory lung disease that is posing a true global health challenge. The genetic basis of the disease is fairly well examined. However, the molecular crosstalk between microRNAs (miRNAs), target genes, and transcription factors (TFs) networks and their contribution to disease pathogenesis and progression is not well explored.

Identification of a de novo LRP1 mutation in a Saudi family with Tetralogy of Fallot.

Background: Tetralogy of Fallot (TOF) is a rare, complex congenital heart defect caused by genetic and environmental interactions that results in abnormal heart development during the early stages of pregnancy. Genetic basis of TOF in Saudi populations is not yet studied. Therefore, the objective of this study is to screen for the molecular defects causing TOF in Saudi patients.

Clinical Characteristics and Implications of Bradycardia in COVID-19 Patients Treated with Remdesivir: A Single-Center Retrospective Cohort Study.

Background And Objectives: Remdesivir is an antiviral drug used to treat coronavirus disease 2019 (COVID-19) with a relatively obscure cardiac effect profile. Previous studies have reported bradycardia associated with remdesivir, but few have examined its clinical characteristics. The objective of this study was to investigate remdesivir associated bradycardia and its associated clinical characteristics and outcomes.

Opioid prescribing practices following bariatric surgery: a systematic review and pooled proportion meta-analysis.

Introduction: A paucity of literature exists regarding current opioid prescribing and use following bariatric surgery. We aimed to characterize opioid prescribing practices and use following bariatric surgery to inform future studies and optimized prescribing practices.

Methods And Procedure: We performed a systematic review of Ovid MEDLINE, Ovid Embase, Scopus, Web of Science Core Collection, and Cochrane Library (via WILEY) on August 20, 2021.