Publications by authors named "Nasser Awwad"

The Crimean Congo virus has been reported to be a part of the spherical RNA-enveloped viruses from the Bunyaviridae family. Crimean Congo fever (CCHF) is a fatal disease with having fatality rate of up to 40%. It is declared endemic by the World Health Organization.

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  • * The review discusses various cancer types where chitosan derivatives show potential benefits, and highlights the need for more comprehensive literature on its applications in both biomedical fields and cancer treatment.
  • * It aims to provide an extensive overview of recent advancements in chitosan derivatives, featuring diagrams and tables to aid understanding for researchers and practitioners in the field.
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Chitosan (Cs), a naturally occurring biopolymer, has garnered significant interest due to its inherent biocompatibility, biodegradability, and minimal toxicity. This study investigates the effectiveness of various reaction strategies, including acylation, acetylation, and carboxymethylation, to enhance the solubility profile of Cs. This review provides a detailed examination of the rapidly developing field of Cs-based metal complexes and nanoparticles.

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In comparison to the lead halide perovskites, nowadays, lead-free halide perovskites have demonstrated a number of benefits, including efficient optical absorption, increased stability, variable bandgap, excellent mobility of carriers, non-toxicity, abundant raw ingredients, and low manufacturing cost. The use of the Perdew-Burke-Ernzerhof (PBE) and Heyd-Scuseria-Ernzerhof (HSE) hybrid functional inside the quantum espresso software allowed for a thorough examination of these materials, potentially leading to improvements in the development of ecologically acceptable and economically sustainable perovskite-based products. This work has extensively examined the effects of compressive and tensile strain on the structural, optical, and electronic characteristics of the inorganic cubic perovskite SrAsX (X = F, Cl, Br) with varying X anion using first-principles density-functional theory (FP-DFT).

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Expression of concern for 'A well-defined S-g-CN/Cu-NiS heterojunction interface towards enhanced spatial charge separation with excellent photocatalytic ability: synergetic effect, kinetics, antibacterial activity, and mechanism insights' by Haya A. Abubshait , , 2022, , 3274-3286, https://doi.org/10.

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  • The expression of concern highlights potential issues regarding the validity of the data and conclusions presented in the paper about the S-scheme heterojunction, which combines g-CN and Co-ZF for improved photocatalytic activity.
  • The authors are being urged to clarify their methods and results to ensure the reliability of their findings related to charge separation and photocatalytic performance under sunlight.
  • This notice reflects the ongoing importance of transparency and rigor in scientific research, aiming to uphold the integrity of published studies in the field.
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Activated carbon (AC) derived from Date pits (DP) wastes was used as an eco-friendly and effective biosorbent for the removal of fluorene (FLU) from organic wastes. The maximum capacity of DP was 6.71 mg g, compatible with the Freundlich model.

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Expression of concern for 'Engineering the optical properties of nickel sulphide thin films by zinc integration for photovoltaic applications' by Junaid Younus , , 2023, , 27415-27422, https://doi.org/10.1039/D3RA04011A.

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Expression of concern for 'Designing a novel visible-light-driven heterostructure Ni-ZnO/S-g-CN photocatalyst for coloured pollutant degradation' by Ali Bahadur , , 2021, , 36518-36527, https://doi.org/10.1039/d0ra09390d.

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  • - A novel heterojunction made of BiMoO/CdS with Ni nanoparticles was created using a solvothermal method and showed significant photocatalytic activity in degrading 2-aminophenol, outperforming individual metal components by 26 and 16 times.
  • - The efficiency of this heterojunction is attributed to a unique S-scheme which enhances the separation of charge carriers, with Ni nanoparticles preventing electron backflow through a Mott Schottky barrier, allowing for a more effective flow in photocatalytic processes.
  • - The structure's 2D-2D morphology increases surface area for better light absorption and reactivity, and its stability over multiple cycles indicates good potential for practical applications and recycling.
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  • Diabetes mellitus (DM) is a growing global health issue associated with multiple health risks, and vildagliptin is a commonly used medication for managing high blood sugar in diabetic patients.
  • The study focused on creating zinc oxide nanoparticles (ZnO NPs) to enhance the effectiveness and reduce side effects of vildagliptin by improving drug retention and hypoglycemic effects.
  • Various characterization methods confirmed the successful synthesis of vildagliptin-loaded ZnO NPs, with in vitro testing showing strong inhibition rates of α-amylase and DPP IV enzymes, suggesting enhanced anti-diabetic activity.
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  • Researchers are focusing on barium-nitride-chloride (BaNCl) hybrid perovskite solar cells (HPSCs) because of their impressive semiconductor qualities.
  • The study examined an electron transport layer (ETL) using TiO and a hole transport layer (HTL) made from CuI in various configurations, analyzing factors like layer thickness and defect densities through SCAPS-1D simulation.
  • The results showed the CuI HTL achieved a power conversion efficiency (PCE) of 30.47% with an open circuit voltage of 1.0649 V and a short circuit current of 38.2609 mA cm, providing valuable insights for developing affordable BaNCl-based thin
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  • * Traditional methods for creating metal nanoparticles are becoming inefficient and harmful, prompting a shift towards more environmentally friendly and cost-effective alternatives, particularly using microbial synthesis.
  • * Microbes can produce nanoparticles in various sizes and shapes using low-cost materials, offering a sustainable and ecological approach to both nanoparticle production and environmental cleanup through bioremediation.
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In this study, biochar (BC) from Delonix regia pods peel and gum from Delonix regia seed (SG) were prepared, and also biochar/chitosan composite (BCS) and biochar/Delonix regia seed gum/chitosan composite (BCGS) were fabricated for the efficient adsorption of phenol. Various characterization tools such as SEM, TEM, ATR-FTIR, TGA, zeta potential, and textural investigation were studied to examine the features of the synthetized adsorbents, confirming their positive construction. It was fully studied how necessary factors, comprising pH, dose of adsorbent, contact shaking time, initial phenol concentration, and temperature influenced adsorption behavior.

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Our study focused on the optical behavior, methylene blue (MB) dye degradation potential, antibacterial performance, and silver and trioxide mineral interaction with different bacterial species. We found that the addition of silver nanoparticles (Ag NPs) to neodymium oxide (NdO) resulted in a significant response, with an enlargement of the inhibition zone for bacterial species such as Staphylococcus aureus and Escherichia coli. Specifically, the inhibition zone for S.

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  • - This study investigates how adding reduced graphene oxide (rGO) and SEBS-g-MA affects the properties of expanded polystyrene (EPS), focusing on its optical, thermal, and mechanical attributes.
  • - Tests showed that the composites had a significantly lower band-gap energy and better thermal stability compared to pristine EPS, along with increased yield strength and Young's modulus, indicating enhanced mechanical performance.
  • - The morphological analysis indicated a transition from an inhomogeneous rGO dispersion to a uniform distribution in the EPS matrix when SEBS-g-MA was included, suggesting improved compatibility between the materials.
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  • The study focuses on creating 2-imino-1,3-thiazolines with fluorinated components by reacting thioureas with a specific brominated compound, achieving good yields.
  • The structural identities of these compounds were confirmed using advanced techniques like FTIR and NMR spectroscopies.
  • Biological tests showed that these compounds effectively inhibit the enzyme α-glucosidase, with one compound demonstrating strong antidiabetic activity and better binding energy compared to a standard drug, indicating its potential as a valuable drug candidate.
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  • Yellow fever is caused by a flavivirus with a specific RNA structure that encodes important proteins, including the NS3 helicase, which is crucial for the virus's function.
  • The study focuses on identifying effective inhibitors for the NS3 helicase by screening 300 ligands based on their chemical similarity to a known compound called -adenosyl-l-cysteine.
  • After computational analyses, the leading inhibitor identified was 2-amino--(4-(dimethylamino)thiazol-2-yl)-4-methyloxazole-5-carboxamide, showing promise for future drug development against yellow fever.
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  • Five solid adsorbents were developed, including calcium alginate beads and composite beads made from Araucaria gum and calcium alginate, characterized through multiple analytical methods.
  • The adsorbents were tested for lead (Pb II) ion removal, with CR11 showing the highest batch and column adsorption capacities of 149.95 mg/g and 161.1 mg/g respectively, under specific conditions.
  • The adsorption process was determined to be spontaneous and endothermic, with CR11 demonstrating fast kinetics and potential effectiveness for water treatment applications despite a slight decrease in capacity after multiple uses.
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  • Thymidine phosphorylase (TP) is essential for tumor growth and angiogenesis, making it an important target for cancer research.
  • The study explored various bis-thiadiazole-based compounds to see how structural changes affect their ability to inhibit TP, resulting in 14 new analogs that showed moderate to good inhibition.
  • Eleven of these newly synthesized analogs outperformed a standard drug in inhibiting TP, and further studies included structure-activity relationship (SAR) analyses and molecular docking to understand their interactions with the enzyme.
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  • The study focuses on developing new cholinesterase inhibitors to treat Alzheimer's disease, specifically investigating pyrimidine-morpholine hybrids as potential drug candidates.
  • Using a palladium-catalyzed reaction, the researchers created diverse compounds and tested their effectiveness, with one compound, 5h, showing significant inhibition against acetylcholinesterase (AChE), being about 38 times more potent than the current drug neostigmine.
  • Additionally, the study includes molecular dynamics simulations and ADME analysis, confirming the stability and drug-like properties of the promising compounds, suggesting they may be developed into effective treatments for Alzheimer's.
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Thin films of binary nickel sulphide (NiS) and zinc-doped ternary nickel sulphides (NiZnS, where = 0-1) were effectively produced by the chemical bath deposition method, and their potential use in photovoltaics were investigated. Dopant inclusion did not change the crystal structure of NiS, according to the structural analysis of the synthesized samples. They are appropriate for solar cell applications since the morphological study verified the crack-free deposition.

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Green synthesis of NPs has gained extensive acceptance as they are reliable, eco-friendly, sustainable, and stable. Chemically synthesized NPs cause lung inflammation, heart problems, liver dysfunction, immune suppression, organ accumulation, and altered metabolism, leading to organ-specific toxicity. NPs synthesized from plants and microbes are biologically safe and cost-effective.

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Targeted delivery of drug molecules to diseased sites is a great challenge in pharmaceutical and biomedical sciences. Fabrication of drug delivery systems (DDS) to target and/or diagnose sick cells is an effective means to achieve good therapeutic results along with a minimal toxicological impact on healthy cells. Biopolymers are becoming an important class of materials owing to their biodegradability, good compatibility, non-toxicity, non-immunogenicity, and long blood circulation time and high drug loading ratio for both macros as well as micro-sized drug molecules.

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