Publications by authors named "Nasser A Al-Harchan"
Article Synopsis
- Vascular dementia (VaD) is the second most common type of dementia after Alzheimer’s disease, characterized by cognitive impairment and memory loss, often linked to cerebral amyloid angiopathy (CAA).
- Early diagnosis and the use of anti-inflammatory treatments can potentially prevent the development of VaD, but there are currently no effective drugs available specifically for its management.
- Statins, commonly used for lowering cholesterol, may show promise in treating VaD and improving cognitive function, but the exact mechanisms of their effectiveness are still not well understood.
COVID-19 pathology is mainly associated to a pulmonary disease which sometimes might result in an uncontrollable storm related to inflammatory diseases which could be fatal. It is well known that phosphodiesterase enzyme type 5 inhibitors (PDE5Is), such as sildenafil, have been successfully developed for the treatment of pulmonary arterial hypertension; interestingly, more recently, it was shown that PDE5Is might be also anti-inflammatory. Therefore, it would be of interest to question about the use of PDE5Is to overcome the COVID-19 storm, as much as PDE5 is mainly present in the lung tissues and vessels.
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