Publications by authors named "Nasrinsadat Mirtalaee"
An investigation into the beneficial effects of high-dose interferon beta 1-a, compared to low-dose interferon beta 1-a in severe COVID-19: The COVIFERON II randomized controlled trial.
Ilad Alavi Darazam Firouze Hatami Mohammad Mahdi Rabiei Mohamad Amin Pourhoseingholi Minoosh Shabani Nasrinsadat Mirtalaee
Int Immunopharmacol
October 2021
Article Synopsis
- A clinical trial investigated the effectiveness of high-dose versus low-dose interferon-beta 1a (IFN-β 1a) for treating severe COVID-19 in hospitalized patients.
- The trial involved 168 participants randomly assigned to receive either a high-dose or low-dose treatment regimen, combined with the antiviral medication lopinavir/ritonavir.
- Results showed that patients receiving low-dose IFN-β 1a experienced a quicker clinical improvement and similar mortality rates compared to those on high-dose treatment, indicating no benefit from the higher dosage.