Case report: Resolution of VIPoma-related symptoms with peptide receptor radionuclide therapy.

Peptide receptor radionuclide therapy (PRRT) is used for the management of neuroendocrine tumors (NETs) not responsive to somatostatin analogs. In this case series, we report two patients with pancreatic vasoactive intestinal peptide (VIP)-secreting NETs (VIPomas) not responsive to any other therapies who achieved symptomatic control and a significant decrease in serum VIP levels with PRRT during their hospital stay. Two patients with VIPomas were admitted to the hospital with multiple prior hospital admissions after going through multiple lines of therapy.

Lacrimal gland uptake of (67)Ga-gallium citrate correlates with biopsy results in patients with suspected sarcoidosis.

Purpose: To investigate whether lacrimal gland uptake on (67)Ga-gallium citrate scintigraphy correlates with histopathologic evidence of sarcoidosis.

Methods: A retrospective, pilot study of 31 patients with suspected sarcoidosis who underwent gallium scintigraphy and lacrimal gland biopsy. Lacrimal gland gallium uptake was assessed by subjective visual scoring (SVS) and lacrimal uptake ratio (LUR).

Physiology and pathophysiology of incidental findings detected on FDG-PET scintigraphy.

A routine feature of positron emission tomography/computed tomography (PET/CT) imaging is whole-body acquisition that results in many unexpected findings identified outside of the primary region of abnormality. Furthermore, (18)F-fluorodeoxyglucose (FDG) is a marker of glycolysis and does not specifically accumulate in malignancy. Understanding the physiology and pathophysiology of normal FDG distribution and common incidental findings is therefore essential to the physician interpreting whole-body FDG-PET/CT studies.

Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach.

Background: Prostate cancer is characterized by a low rate of glycolysis and glucose uptake. We hypothesize that fatty acid is dominant over glucose in uptake by prostate cells.

Materials And Methods: One benign (RWPE1) and two malignant (LNCaP and PC3) prostate cell lines were assayed for their in vitro uptake of radiolabeled glucose analogs (3)H-fluoro-2-deoxyglucose and (18)F-fluoro-2-deoxyglucose, and the long-chain fatty acid (3)H-palmitic acid.

18F-FDG PET evaluation of sinonasal papilloma.

Objective: It has been suggested that (18)F-FDG uptake determined by PET can differentiate squamous cell carcinoma from benign sinonasal papilloma. We wish to present our experience with sinonasal papillomas and PET/CT to determine if the degree of FDG uptake is indicative of benign or malignant disease.

Conclusion: Benign sinonasal papilloma may be associated with intense FDG uptake on PET/CT.

Use of whole-body FDG PET-CT to aid in the diagnosis of occult sarcoidosis.

Purpose: To report a case where combined whole-body Fluorine-18 fluorodeoxyglucose (FDG) PET-CT scanning was used to aid in the diagnosis of a patient with occult sarcoidosis.

Design: Case report.

Methods: FDG PET-CT scanning was performed in a patient who presented with persistent bilateral panuveitis after cataract surgery and had undergone an extensive negative workup.

Tc-99m red blood cell scintigraphic detection of CMV-induced small bowel hemorrhage.

A 4-month-old female child, recently diagnosed with parentally-acquired HIV complicated by moderate immunosuppression and pneumocystis carinii pneumonia (PCP), presented with hematochezia. A Tc-99m bleeding study was performed and demonstrated a site of brisk bleeding in the distal ileum. The patient was taken to the operating room and resection of the distal ileum revealed the presence of cytomegalovirus (CMV) enteritis.

The F + 0 protocol for diuretic renography results in fewer interrupted studies due to voiding than the F - 15 protocol.

Unlabelled: Timing of diuretic administration is not universally standardized in renography. Over the past year, our practice has changed from F-15 administration of furosemide to an F + 0 protocol. Therefore, we have retrospectively compared these 2 cohorts to assess if the shorter interval between diuretic administration and study completion in the F + 0 study results in a greater frequency of patients able to complete the subsequent 30-min dynamic acquisition without disruption due to voiding.

Fluorodeoxyglucose positron emission tomography excludes pericardial metastasis by recurrent lung cancer.

Fluorodeoxyglucose (FDG) positron emission tomography (PET) has been shown to be useful in the diagnosis and staging of a variety of malignancies. Because of its high sensitivity, FDG PET frequently detects malignant lesions that are not demonstrated clearly by anatomic imaging modalities. FDG PET usually has high negative predictive value and, therefore, negative studies are highly suggestive of a benign process.