Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials.

Objective: To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying cardiovascular and renal risk.

Design: Network meta-analysis.

Data Sources: Medline, Embase, and Cochrane CENTRAL up to 11 August 2020.

Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes: A Meta-analysis.

Importance: Numerous glucose-lowering drugs are used to treat type 2 diabetes.

Objective: To estimate the relative efficacy and safety associated with glucose-lowering drugs including insulin.

Data Sources: Cochrane Library Central Register of Controlled Trials, MEDLINE, and EMBASE databases through March 21, 2016.