Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines.

Redox homeostasis is the vital regulatory system with respect to antioxidative response and detoxification. The imbalance of redox homeostasis causes oxidative stress. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) signaling is the major regulator of redox homeostasis.

EGFR-Based Targeted Therapy for Colorectal Cancer-Promises and Challenges.

Colorectal carcinoma (CRC) is the most lethal and common form of cancer in the world. It was responsible for almost 881,000 cancer deaths in 2018. Approximately 25% of cases are diagnosed at advanced stages with metastasis-this poses challenges for effective surgical control and future tumor-related mortality.

Visual status among undergraduate students: Findings from an emerging university in Saudi Arabia.

Background: Refractive error is an important preventable cause of visual impairment and blindness worldwide. In adult life, reduced vision can potentially affect the academic performance, choice of occupation and socio-economic status. This study aimed to assess the prevalence of refractive errors and related visual impairment among undergraduate male students in Prince Sattam bin Abdulaziz University in Al-Kharj, Saudi Arabia.

Awareness among the general population about lipid profile screening in individuals over 20 years old in Alriyadh, Saudi Arabia.

Introduction: Plasma cholesterol and triglycerides are clinically important because their abnormally high levels are major treatable risk factors for cardiovascular disease. This study aimed to evaluate the awareness, general knowledge, and attitudes about regular lipid profile screening among adult individuals in Al-Riyadh.

Material And Methods: This is a cross-sectional study collected by convenience sampling method.