Communicating with Stakeholders to Identify High-Impact Research Directions for Non-Targeted Analysis.

Non-targeted analysis (NTA) using high-resolution mass spectrometry without defined chemical targets has the potential to expand and improve chemical monitoring in many fields. Despite rapid advancements within the research community, NTA methods and data remain underutilized by many potential beneficiaries. To better understand barriers toward widespread adoption, the Best Practices for Non-Targeted Analysis (BP4NTA) working group conducted focus group meetings and follow-up surveys with scientists (n = 61) from various sectors (e.

PFAS remediation in soil: An evaluation of carbon-based materials for contaminant sequestration.

The presence of per- and poly-fluoroalkyl substances (PFAS) in soils is a global concern as these emerging contaminants are highly resistant to degradation and cause adverse effects on human and environmental health at very low concentrations. Sequestering PFAS in soils using carbon-based materials is a low-cost and effective strategy to minimize pollutant bioavailability and exposure, and may offer potential long-term remediation of PFAS in the environment. This paper provides a comprehensive evaluation of current insights on sequestration of PFAS in soil using carbon-based sorbents.

Investigation of Sources of Fluorinated Compounds in Private Water Supplies in an Oil and Gas-Producing Region of Northern West Virginia.

Per- and polyfluoroalkyl substances (PFASs) are a class of toxic organic compounds that have been widely used in consumer applications and industrial activities, including oil and gas production. We measured PFAS concentrations in 45 private wells and 8 surface water sources in the oil and gas-producing Doddridge, Marshall, Ritchie, Tyler, and Wetzel Counties of northern West Virginia and investigated relationships between potential PFAS sources and drinking water receptors. All surface water samples and 60% of the water wells sampled contained quantifiable levels of at least one targeted PFAS compound, and four wells (8%) had concentrations above the proposed maximum contaminant level (MCL) for perfluorooctanoic acid (PFOA).

Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.

Background: Pediatric thyroid diseases have been increasing in recent years. Environmental risk factors such as exposures to chemical contaminants may play a role but are largely unexplored. Archived neonatal dried blood spots (DBS) offer an innovative approach to investigate environmental exposures and effects.

How should multiple myeloma research change in a patient-oriented world? Findings and lessons from the pan-Canadian myeloma priority setting partnership.

Background: Over the last decade there has been considerable research into the treatment, management, and quality of life of people living with multiple myeloma. However, there has been limited investigation into topics deemed important to patients and caregivers within this community. We conducted a James Lind Alliance Priority Setting Partnership to establish the 'Top 10 Priorities for Myeloma Research', informed by patient and public partners.

Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.

Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been widely used in consumer, personal care, and household products for their stain- and water-repellent properties. PFAS exposure has been linked to various adverse health outcomes. Such exposure has commonly been evaluated in venous blood samples.

from the Fire Blight Biocontrol Product, Blossom Protect, Induces Host Resistance in Apple Flowers.

Fire blight, caused by , is a devastating disease of apple. Blossom Protect, a product that contains as the active ingredient, is one of the most effective biological controls of fire blight. It has been postulated that the mode of action of is to compete against and antagonize epiphytic growth of on flowers, but recent studies have found that flowers treated with Blossom Protect harbored similar to or only slightly reduced populations compared with nontreated flowers.

Assessing the fate of antibiotics and agrochemicals during anaerobic digestion of animal manure.

Antibiotics and pesticides are used extensively by the livestock industry. Agricultural chemicals can pose potential human and environmental health risks due to their toxicity and through their contributions to antimicrobial resistance, and strategies to reduce their emission into the environment are urgently needed. Anaerobic digestion (AD) is a sustainable technology for manure management that produces biogas while also providing an opportunity to degrade agricultural chemicals that are present in manure.

A Light-Tolerant Wireless Neural Recording IC for Motor Prediction With Near-Infrared-Based Power and Data Telemetry.

Miniaturized and wireless near-infrared (NIR) based neural recorders with optical powering and data telemetry have been introduced as a promising approach for safe long-term monitoring with the smallest physical dimension among state-of-the-art standalone recorders. However, a main challenge for the NIR based neural recording ICs is to maintain robust operation in the presence of light-induced parasitic short circuit current from junction diodes. This is especially true when the signal currents are kept small to reduce power consumption.

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice.

Long-term glucagon receptor (GCGR) agonism is associated with hyperglycemia and glucose intolerance, while acute GCGR agonism enhances whole-body insulin sensitivity and hepatic AKTSer473 phosphorylation. These divergent effects establish a critical gap in knowledge surrounding GCGR action. mTOR complex 2 (mTORC2) is composed of seven proteins, including RICTOR, which dictates substrate binding and allows for targeting of AKTSer473.

A Light Tolerant Neural Recording IC for Near-Infrared-Powered Free Floating Motes.

A key challenge for near-infrared (NIR) powered neural recording ICs is to maintain robust operation in the presence of parasitic short circuit current from junction diodes when exposed to light. This is especially so when intentional currents are kept small to reduce power consumption. We present a neural recording IC that is tolerant up to 300 μW/mm light exposure (above tissue limit) and consumes 0.

Muscle Activity During Immersive Virtual Reality Exergaming Incorporating an Adaptive Cable Resistance System.

The purpose of this exploratory study was to characterize muscle activation via surface electromyography (sEMG), user-perceived exertion, and enjoyment during a 30-minute session of immersive virtual reality (IVR) cable resistance exergaming. Ten healthy, college-aged males completed a signature 30-minute exergaming session using an IVR adaptive cable resistance system that incorporated six traditional compound exercises. Muscle activation (sEMG) was captured during the session with a wearable sEMG system.

An Introduction to the Benchmarking and Publications for Non-Targeted Analysis Working Group.

Non-targeted analysis (NTA) encompasses a rapidly evolving set of mass spectrometry techniques aimed at characterizing the chemical composition of complex samples, identifying unknown compounds, and/or classifying samples, without prior knowledge regarding the chemical content of the samples. Recent advances in NTA are the result of improved and more accessible instrumentation for data generation and analysis tools for data evaluation and interpretation. As researchers continue to develop NTA approaches in various scientific fields, there is a growing need to identify, disseminate, and adopt community-wide method reporting guidelines.

Changes in Sewage Sludge Chemical Signatures During a COVID-19 Community Lockdown, Part 2: Nontargeted Analysis of Sludge and Evaluation with COVID-19 Metrics.

Sewage sludge and wastewater include urine and feces from an entire community, and it is highly likely that this mixture contains chemicals whose presence is dependent on levels of SARS-CoV-2 in the community. We analyzed primary sewage sludge samples collected in New Haven, Connecticut, USA, during the initial wave of the COVID-19 pandemic using liquid chromatography coupled with high-resolution mass spectrometry and performed an exploratory investigation of correlations between chemical features and COVID-19 metrics including concentrations of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) RNA in the sludge and local COVID-19 case numbers and hospital admissions. Inclusion of all chemical features in this analysis is key for discovering potential indicator compounds for COVID-19, whose structures may not be known.

Changes in Sewage Sludge Chemical Signatures During a COVID-19 Community Lockdown, Part 1: Traffic, Drugs, Mental Health, and Disinfectants.

The early months of the COVID-19 pandemic and the associated shutdowns disrupted many aspects of daily life and thus caused changes in the use and disposal of many types of chemicals. While records of sales, prescriptions, drug overdoses, and so forth provide data about specific chemical uses during this time, wastewater and sewage sludge analysis can provide a more comprehensive overview of chemical changes within a region. We analyzed primary sludge from a wastewater-treatment plant in Connecticut, USA, collected March 19 to June 30, 2020.

Explanatory Journeys: Visualising to Understand and Explain Administrative Justice Paths of Redress.

Administrative justice concerns the relationships between individuals and the state. It includes redress and complaints on decisions of a child's education, social care, licensing, planning, environment, housing and homelessness. However, if someone has a complaint or an issue, it is challenging for people to understand different possible redress paths and explore what path is suitable for their situation.

Real-time linear prediction of simultaneous and independent movements of two finger groups using an intracortical brain-machine interface.

Modern brain-machine interfaces can return function to people with paralysis, but current upper extremity brain-machine interfaces are unable to reproduce control of individuated finger movements. Here, for the first time, we present a real-time, high-speed, linear brain-machine interface in nonhuman primates that utilizes intracortical neural signals to bridge this gap. We created a non-prehensile task that systematically individuates two finger groups, the index finger and the middle-ring-small fingers combined.

Restoring upper extremity function with brain-machine interfaces.

One of the most exciting advances to emerge in neural interface technologies has been the development of real-time brain-machine interface (BMI) neuroprosthetic devices to restore upper extremity function. BMI neuroprostheses, made possible by synergistic advances in neural recording technologies, high-speed computation and signal processing, and neuroscience, have permitted the restoration of volitional movement to patients suffering the loss of upper-extremity function. In this chapter, we review the scientific and technological advances underlying these remarkable devices.

Bridging the"Last Millimeter" Gap of Brain-Machine Interfaces via Near-Infrared Wireless Power Transfer and Data Communications.

Arrays of floating neural sensors with high channel count that cover an area of square centimeters and larger would be transformative for neural engineering and brain-machine interfaces. Meeting the power and wireless data communications requirements within the size constraints for each neural sensor has been elusive due to the need to incorporate sensing, computing, communications, and power functionality in a package of approximately 100 micrometers on a side. In this work, we demonstrate a near infrared optical power and data communication link for a neural recording system that satisfies size requirements to achieve dense arrays and power requirements to prevent tissue heating.