Designed Synthesis of Amino-Azo-Quinoline and their Nickel(II) Complexes: Molecular Structure, Electrochemistry and an Insight into their in vitro Anti-Cancer Activities.

Amino-quinolines are potential candidates that may provide some insight into the current chemotherapeutic research due to their demonstrated anti-cancer activity. This led us to synthesize and explore a new amino-azo-quinoline ligand H2L 1 and its square planar nickel(II) complexes [Ni(HL)(OAc)], 2 and [Ni(HL)Cl], 3 and the structures were determined by SCXRD. Theoretical investigation of redox orbitals of the complexes discloses that the reduction process is due to ligand reduction whereas both metal and ligand are contributing towards oxidation.

Structure-directing effect of terephthalate in bridging Zn(II)- and Cd(II)-based coordination polymers towards application in the detection of trace quantities of Pd in aqueous media and their electrical conductivities.

Energy crisis and environmental pollution are two central themes of contemporary research towards achieving sustainable development goals (SDGs). Material chemistry is the chief discipline that can resolve glitches in these areas through the appropriate design of chemical compounds with multifunctional properties. In this regard, two stable coordination polymers (CPs) were synthesised in this work using Zn(II) (3d) and Cd(II) (d) metal nodes with 1,4-benzenedicarboxylate () as the bridging ligand and monodentate pyridyl-N coordinated 9-fluoren-2-yl-pyridin-4-ylmethylene-amine (flpy) as the fluorogenic partner.

Structural determinants of oxygen resistance and Zn-mediated stability of the [FeFe]-hydrogenase from .

[FeFe]-hydrogenases catalyze the reversible two-electron reduction of two protons to molecular hydrogen. Although these enzymes are among the most efficient H-converting biocatalysts in nature, their catalytic cofactor (termed H-cluster) is irreversibly destroyed upon contact with dioxygen. The [FeFe]-hydrogenase CbA5H from has a unique mechanism to protect the H-cluster from oxygen-induced degradation.

The biomedical applications of artificial intelligence: an overview of decades of research.

A significant area of computer science called artificial intelligence (AI) is successfully applied to the analysis of intricate biological data and the extraction of substantial associations from datasets for a variety of biomedical uses. AI has attracted significant interest in biomedical research due to its features: (i) better patient care through early diagnosis and detection; (ii) enhanced workflow; (iii) lowering medical errors; (v) lowering medical costs; (vi) reducing morbidity and mortality; (vii) enhancing performance; (viii) enhancing precision; and (ix) time efficiency. Quantitative metrics are crucial for evaluating AI implementations, providing insights, enabling informed decisions, and measuring the impact of AI-driven initiatives, thereby enhancing transparency, accountability, and overall impact.

Magnetic-proximity-induced anomalous Hall effect at the EuO/SbTeinterface.

Time-reversal symmetry breaking of a topological insulator phase generates zero-field edge modes which are the hallmark of the quantum anomalous Hall effect (QAHE) and of possible value for dissipation-free switching or non-reciprocal microwave devices. But present material systems exhibiting the QAHE, such as magnetically doped bismuth telluride and twisted bilayer graphene, are intrinsically unstable, limiting their scalability. A pristine magnetic oxide at the surface of a TI would leave the TI structure intact and stabilize the TI surface, but epitaxy of an oxide on the lower-melting-point chalcogenide presents a particular challenge.

Harnessing thermal waste with a poling-free molecular pyroelectric zinc(II) complex.

Transforming abundant thermal energy into electrical energy is an essential and sustainable solution to meet the rapidly growing global energy demand. In this communication, we report an electrical poling-free molecular complex [Zn(bpy)](ClO)·HO (1) with an appreciable pyroelectric coefficient value of 25 μC m K. This allowed us to harvest waste heat energy using a pyroelectric nanogenerator (PyG) device of 1, a relatively unexplored area for molecular complexes.

Light-regulated pyro-phototronic effects in a perovskite CsSnI-reinforced ferroelectric polymer hybrid nanostructure.

The 'pyro-phototronic effect' plays a nontrivial role in advancing ferroelectric (FE) devices of light detectors, light-emitting diodes, and other smart technologies. In this work, a premier FE copolymer, poly(vinylidene fluoride--trifluoro ethylene) (P(VDF-TrFE)), is reinforced with a lead-free double perovskite, CsSnI, to render profound properties in a hybrid nanostructure. It presents a unique example of the coupling of ferro-, pyro- and piezo-electrics to the 'photoexcitation' of exotic charges that actively empower the synergetic features.

Dehydrogenative Coupling for Synthesis of Quinazolin-4(3H)-ones via Tandem Reaction using Ruthenium(II)-Phenyl-Azo-Naphthaldoxime: An Experimental and Theoretical Investigation.

The bidentate N, N, donor phenyl-azo-naphthaldoxime NpLH, 1 was used to synthesize the ruthenium(II) complex trans-[Ru(NpL)(CO)Cl(PPh)], 2. It has been characterized by SCXRD, electrochemical and spectral studies. Computational analysis indicates that the low-lying π*-LUMO of the complex has substantial azo-character of coordinated ligand.

Development and optimization of an efficient RNA isolation protocol from bovine () spermatozoa.

Achieving the optimum extraction of RNA from spermatozoal cells is crucial for carrying out effective high-throughput analysis regarding its role in fertility and other reproduction processes in . Nevertheless, semen comprises spermatozoa and several other secretions from the male reproductive system, which as well consist of diverse somatic cell types. Therefore, the elimination of somatic cells guarantees the purity of the sperm RNA.

Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair.

The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as well as 3D rings and helical polymers, all implicated in mitigating plastid-associated membrane stress. The architecture of Vipp1 planar sheets and helical polymers remains unknown, as do the geometric changes required to transition between polymeric forms.

Lower expressions of MIR34A and MIR31 in colo-rectal cancer are associated with an enriched immune microenvironment.

Introduction: MicroRNAs (MIRs) play a crucial role in colorectal cancer (CRC) development and metastasis by regulating immune responses. Tumour-infiltrating lymphocytes (TILs) are an important predictive factor in many cancers, but, their association with microRNAs have not been studied well in colorectal cancer. Three microRNAs (MIR34A, MIR31 & MIR21), the roles of which in tumorigenesis is well-studied and which also possess immunomodulatory effect, were identified by extensive literature search.

Glycogen synthase kinase 3 (GSK3) inhibition: a potential therapeutic strategy for Alzheimer's disease.

Alzheimer's disease (AD), the most common type of dementia among older adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive functioning with a decline of rational skills. It is well known that AD is multifactorial, so there are many different pharmacological targets that can be pursued. According to estimates from the World Health Organization (WHO), 18 million individuals worldwide suffer from AD.

Machine Learning-Enabled Nanoscale Phase Prediction in Engineered Poly(Vinylidene Fluoride).

Engineered poly(vinylidene fluoride) (PVDF) with its diverse crystalline phases plays a crucial role in determining the performance of devices in piezo-, pyro-, ferro- and tribo-electric applications, indicating the importance of distinct phase-detection in defining the structure-property relation. However, traditional characterization techniques struggle to effectively distinguish these phases, thereby failing to offer complete information. In this study, multimodal data-driven techniques have been employed for distinguishing different phases with a machine learning (ML) approach.

Polystyrene Chain Geometry Probed by Ion Mobility Mass Spectrometry and Molecular Dynamics Simulations.

Polystyrene (PS) is a thermoplastic polymer commonly used in various applications due to its bulk properties. Designing functional polystyrenes with well-defined structures for targeted applications is of significant interest due to the rigid and apolar nature of the polymer chain. Progress is hindered to date by the limitations of current analytical methods in defining the atomistic-level folding of the polymer chain.

Room Temperature Single-Component Organic Multiferroics with Large Magnetoelectric Coupling: Proficient Approach for Stray-Magnetic Field Harvesting.

Magnetoelectric materials are highly desirable for technological applications due to their ability to produce electricity under a magnetic field. Among the various types of magnetoelectric materials studied, their organic counterparts provide an opportunity to develop solution-processable, flexible, lightweight, and wearable electronic devices. However, there is a rare choice of solution-processable, flexible, lightweight magnetoelectric materials which has tremendous technological interest.

Effect of mindfulness-based intervention on perceived stress among breast cancer patients undergoing chemotherapy.

Introduction: Breast cancer is the second most prevalent disease among women in India and one of the most dangerous and lethal. Chemotherapy-treated breast cancer patients may have perceived stress, which is defined as emotions of mental or physical exhaustion that make them feel angry or anxious. Mindfulness-based intervention (MBI) gives some ideas in line with the conventional mindfulness technique.

Acid-Mediated Modulation of the Conductance of Diazapentalene Molecular Junctions.

We report an acid-mediated regulation of single-molecule junction conductance achieved using an electron-deficient unit, diazapentalene, functionalized with thiophene extending units and thiomethyl aurophilic terminal groups. This diazapentalene derivative exhibits a protonation reaction in the presence of trifluoroacetic acid, as characterized by UV-vis absorption spectroscopy, and the protonated species shows a voltage-dependent single-molecule conductance, which is not observed for the pristine molecules. Specifically, under a high bias voltage of 850 mV, we observe a conductance value for the protonated molecule larger than that for the deprotonated one by a factor of 4.

Polyurethane/Carbon Nanotube-Based ThermoSense Electronic Skin: Perception to Decision Making Aided by Internet of Things Brain.

Human skin has several receptors collaborating with the brain to provide appropriate "decisions" when applying stimuli. Several research articles state that biomimetic electronic skin (e-skin) is reportedly used for sensor-related applications and performs similarly to natural skin. However, research reporting the capability of the e-skin to make decisions and therefore react upon exposure to adverse conditions is still in its nascent stage.

Cytoplasmic Expression of p16 Is Associated with Carcinoma Breast: It Is Not an Artifact.

Background & Objective: p16 has different roles in the nuclear and cytoplasmic locations. The nuclear localization of the p16 protein explains its role in cell cycle regulation. Cytoplasmic expression was considered an artifact in the initial years, but there is evidence to prove that cytoplasmic localization is real and that p16 has different roles in the nuclear and cytoplasmic locations.

Distribution of Infectious Disease Outbreaks in India before and after the COVID-19 Pandemic: Analysis of National Weekly Surveillance Data.

National surveillance data were collected to study the outbreak trends of infectious diseases/syndromes before and during the COVID-19 pandemic period, spanning from 2018 to 2022. The study found that out of 4208 outbreaks, 2972 occurred before the COVID-19 period, affecting 147,425 people, while 1236 outbreaks affected 52,324 people during the pandemic. The number of outbreaks for diseases such as acute flaccid paralysis, fever with rashes, leptospirosis, rabies, and scrub typhus increased during the pandemic.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.

In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools to access and manipulate fine neuronal subtypes are still limited. Here, we performed systematic analysis of single cell genomic data to identify enhancer candidates for each of the cortical interneuron subtypes.

Tumor antigen presentation and the associated signal transduction during carcinogenesis.

Numerous developments have been achieved in the study and treatment of cancer throughout the decades that it has been common. After decades of research, about 100 different kinds of cancer have been found, each with unique subgroups within certain organs. This has significantly expanded our understanding of the illness.

Active mechanical cloaking for unsupervised damage resilience in programmable elastic metamaterials.

Owing to the architected void-filled low-density configurations, metamaterials are prone to defects during the complex manufacturing process, or damages under operational conditions. Recently mechanical cloaking has been proposed to shield the effect of such disorders in terms of homogenized mechanical responses. The major drawback in these studies are that the damage location should be known , and the cloak is designed around that damaged zone before manufacturing.