Analogues of 2'-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase.

A series of C4-substituted tertiary nitrogen-bearing 2'-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2'-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). Among them, compound was identified as the most potent AChE inhibitor (IC: 3.

Current approaches in antiviral drug discovery against the Flaviviridae family.

Viruses belonging to the Flaviviridae family primarily spread through arthropod vectors, and are the major causes of illness and death around the globe. The Flaviviridae family consists of 3 genera which include the Flavivirus genus (type species, yellow fever virus) as the largest genus, the Hepacivirus (type species, hepatitis C virus) and the Pestivirus (type species, bovine virus diarrhea). The flaviviruses (Flavivirus genus) are small RNA viruses transmitted by mosquitoes and ticks that take over host cell machinery in order to propagate.

2-(2-Meth-oxy-phen-oxy)pyrazine.

A significant twist is observed in the title molecule, C(11)H(10)N(2)O(2), as seen in the dihedral angle between the pyrazine and benzene rings of 72.79 (8)°. The meth-oxy group is almost coplanar with the benzene ring to which it is attached [C-O-C-C torsion angle = 175.

2-(Naphthalen-2-yl-oxy)-5-nitro-pyridine.

A nearly orthogonal relationship is found for the ring systems in the title compound, C(15)H(10)N(2)O(3), with the dihedral angle between the rings being 86.13 (11)°. The nitro group is approximately coplanar with the pyridine ring to which it is connected [the O-N-C-C torsion angle = -1.

2-(4-Methyl-phen-oxy)-5-nitro-pyridine.

The title mol-ecule, C(12)H(10)N(2)O(3), is twisted, the dihedral angle between the rings being 61.16 (13)°. The nitro group is approximately coplanar with the pyridine ring to which it is attached [O-N-C-C torsion angle = -178.

Tetra-μ-acetato-κO:O'-bis-[(2-phen-oxy-pyrimidine-κN)copper(II)](Cu-Cu).

The complete dinuclear mol-ecule of the title complex, [Cu(2)(CH(3)COO)(4)(C(10)H(8)N(2)O)(2)], is generated by a centre of inversion. The Cu(II) atom is in a distorted octa-hedral coordination geometry defined by four O atoms derived from four bridging acetate ligands, a terminally connected pyrimidine N atom and a Cu atom.

2-(2-Meth-oxy-phen-oxy)-3-nitro-pyridine.

In the title compound, C(12)H(10)N(2)O(4), the pyridine and benzene rings are almost orthogonal, forming a dihedral angle of 86.63 (6)°. Each of the nitro [O-N-C-C torsion angle = -6.

2-(4-Meth-oxy-phen-oxy)-3-nitro-pyridine.

In the title mol-ecule, C(12)H(10)N(2)O(4), the pyridine and benzene rings are almost orthogonal [dihedral angle = 86.69 (11)°], with the pyridine N atom directed towards the centre of the benzene ring. The -NO(2) [O-N-C-C = -26.

2-(4-Meth-oxy-phen-oxy)pyrazine.

In the title compound, C(11)H(10)N(2)O(2), the aromatic rings are almost orthogonal to each other [dihedral angle = 86.97 (8)°], with the benzene ring orientated to face one of the pyrazine N atoms. In the crystal, centrosymmetrically related pairs are connected via pairs of C-H⋯π inter-actions and the dimeric units thus formed pack into undulating layers that stack along the a axis.

2-(Pyrimidin-2-yl-oxy)phenol.

The pyrimidine and benzene rings in the title compound, C(10)H(8)N(2)O(2), form a dihedral angle of 71.03 (7)°, with the roughly orthogonal benzene ring being folded towards one of the pyrimidine N atoms. In the crystal, pairs of O-H⋯N hydrogen bonds connect mol-ecules related by twofold symmetry into dimeric aggregates.

2-(3-Meth-oxy-phen-oxy)pyrimidine.

In the title compound, C(11)H(10)N(2)O(2), the benzene ring faces towards one of the pyrimidine N atoms, and is almost orthogonal to the plane through the pyrimidine ring [dihedral angle = 84.40 (14)°]. In the crystal, the presence of C-H⋯π and π-π [centroid-centroid separation = 3.

2-(2-Naphth-yloxy)pyrimidine.

In the title compound, C(14)H(10)N(2)O, the organic rings are inclined at an angle of 86.1 (1)°. The angle at the ether O atom is widened to 117.

2-(o-Tol-yloxy)pyrimidine.

The title compound, C(11)H(10)N(2)O, crystallizes with two mol-ecules in the asymmetric unit. The angle at the ether O atom is widened to 118.13 (15)° [117.

2-(p-Tol-yloxy)pyrimidine.

In the title compound, C(11)H(10)N(2)O, the aromatic rings make a dihedral angle of 76.3 (1)°. The C-O-C angle at the ether atom is widened to 117.

4-Amino-2-phenoxy-pyrimidine.

In the title compound, C(10)H(9)N(3)O, the organic rings linked to the ether O atom make a dihedral angle of 76.8 (1)° and the C-O-C angle is widened to 119.07 (15)°.

3-Nitro-phenyl pyrimidin-2-yl ether.

In the title compound, C(10)H(7)N(3)O(3), the dihedral angle between the two aromatic rings is 87.5 (1) Å; their ipso-C atoms subtend an angle of 117.4 (1)° at the ether O atom.

N-(Pyrimidin-2-yl)aniline.

There are two molecules in the asymmetric unit of the title compound, C(10)H(9)N(3), with inter-ring dihedral angles of 31.1 (1) and 35.3 (1)°.

2-Phenoxy-pyrimidine.

There are two molecules in the asymmetric unit of, C(10)H(8)N(2)O, with dihedral angles between the aromatic ring planes of 75.9 (1) and 79.3 (1)°.