Comparative Evaluation of pH and Cytotoxicity of Zinc Oxide-Ozonated Eugenol and Conventional Zinc Oxide Eugenol as Endodontic Sealers.

Background: Eugenol released from zinc oxide eugenol (ZOE)-based sealants may cause irritation to the periapical tissues and has cytotoxic potential. Ozone therapy has numerous clinical applications with humans because of its bactericidal action, detoxifying effect, stimulation of angiogenesis, and wound-healing capacity. Therefore ozone can be incorporated in ZOE sealer to exploit these properties.