Effects of α-tocopherol and ascorbic acid in the severity and management of traumatic brain injury in albino rats.

Background: Traumatic brain injury (TBI) is accompanied by substantial accumulation of biomarkers of oxidative stress and depletion of antioxidants reserve which initiate chain reactions that damage brain cells. The present study investigated the role of ascorbic acid and α-tocopherol on the severity and management of TBI in rats.

Materials And Methods: Wistar rats were subjected to closed head injury using an accelerated impact device.