Pantothenate synthetase protein plays a pivotal role in the biosynthesis of coenzyme A (CoA), which is a crucial molecule involved in a number of cellular processes including the metabolism of fatty acid, energy production, and the synthesis of various biomolecules, which is necessary for the survival of (). Therefore, inhibiting this protein could disrupt CoA synthesis, leading to the impairment of vital metabolic processes within the bacterium, ultimately inhibiting its growth and survival. This study employed molecular docking, structure-based virtual screening, and molecular dynamics (MD) simulation to identify promising phytochemical compounds targeting pantothenate synthetase for tuberculosis (TB) treatment.
View Article and Find Full Text PDFThe cytotoxic, antioxidant, anticancer, and antibacterial properties of ethanolic extracts from is of interest. Plants of were gathered from the southern Saudi Arabian region of Albaha. extract was assessed using DPPH (2, 2-diphenyl-1-picrylhydrazyl).
View Article and Find Full Text PDFThe Aja and Salma mountains in the Hail region are home to a variety of indigenous wild plants, some of which are used in Bedouin folk medicine to treat various ailments. The purpose of the current study was to unveil the chemical, antioxidant and antibacterial properties of (Showeka) grown widely in these mountains, as data on the biological activities of this plant in this remote area are scarce. XRF spectrometry indicated the presence of some essential elements, which were in the order of Ca > S > K > AL > CL > Si > P > Fe > Mg > Na > Ti > Sr > Zn > Mn.
View Article and Find Full Text PDFBackground: The excessive concentration of leptin has negative effects on all aspects of female reproduction. Despite this established relationship, the exact role of leptin in women's fertility is not clear enough and needs more clarification.
Aim: To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility (UI).
The innovative study was carried out to produce nano-cellulose based bioplastic biomaterials for vehicle use coming after bioprocess technology. The data show that nano-cellulose particle size was 20 nm and negligible water absorption was 0.03% in the bioplastic.
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