Publications by authors named "Nasir A Butt"

Article Synopsis
  • Prostate cancer often spreads to the bone, causing severe health issues, and the protein MTA1 is found in high levels in metastatic tumors, though its specific function is still unclear.
  • Research revealed that silencing MTA1 reduces tumor growth and bone metastasis formation in various cancer models by affecting the cells' ability to invade and migrate.
  • MTA1 affects the expression of cathepsin B (CTSB), a key player in bone metastasis, while increasing E-cadherin levels, suggesting that targeting the MTA1/CTSB pathway could help prevent bone metastasis in prostate cancer.
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The metastasis-associated protein 1(MTA1)/histone deacetylase (HDAC) unit is a cancer progression-related epigenetic regulator, which is overexpressed in hormone-refractory and metastatic prostate cancer (PCa). In our previous studies, we found a significantly increased MTA1 expression in a prostate-specific Pten-null mouse model. We also demonstrated that stilbenes, namely resveratrol and pterostilbene (Pter), affect MTA1/HDAC signaling, including deacetylation of tumor suppressors p53 and PTEN.

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The androgen receptor (AR) is a therapeutic target for the treatment of prostate cancer. Androgen receptor reactivation during the androgen-independent stage of prostate cancer is mediated by numerous mechanisms including expression of AR mutants and splice variants that become non-responsive to conventional anti-androgenic agents. Resveratrol and its natural analogs exhibit varying degrees of anti-androgenic effects on tumor growth suppression in prostate cancer.

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