Breaking boundaries: role of the brain barriers in metastatic process.

Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3-10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. BMs predominantly originate from primary lung (20-56%), breast (5-20%), and melanoma (7-16%) tumors, although they can arise from other cancer types less frequently.

Corrigendum to ''The predictors of social capital in agricultural consultation, technical, and engineering service companies" [Heliyon, Volume , Issue 1, 15 January 2024, e23853].

[This corrects the article DOI: 10.1016/j.heliyon.

Advanced technologies towards improved HPV diagnostics.

Persistent infection with high-risk types of human papillomaviruses (HPV) is a major cause of cervical cancer, and an important factor in other malignancies, for example, head and neck cancer. Despite recent progress in screening and vaccination, the incidence and mortality are still relatively high, especially in low-income countries. The mortality and financial burden associated with the treatment could be decreased if a simple, rapid, and inexpensive technology for HPV testing becomes available, targeting individuals for further monitoring with increased risk of developing cancer.

The predictors of social capital in agricultural consultation, technical, and engineering service companies.

Social capital is an essential type of capital that influences the growth and development of societies. The present descriptive-survey research aimed to capture CEOs' social capital predictors in the agricultural consultation, technical, and engineering service companies in Fars province, Iran. The CEOs, who amounted to 107 people, all participated in the research.

Strategic sustainability practices in intercropping-based family farming systems: study on rural communities of Iran.

This paper reports a realistic analysis of a region using Grounded Theory (GT) to provide a sustainable model for family farming systems based on the intercropping system in rural communities of Iran. Furthermore, the fuzzy analytic hierarchy process (FAHP) was applied to assign weights to the criteria and sub-criteria of intercropping and monocropping systems. According to the model, the main phenomenon was "sustainability in the family farming system based on intercropping".

Electrochemical bioassay coupled to LAMP reaction for determination of high-risk HPV infection in crude lysates.

Electrochemical (EC) detection of DNA biomarkers represents an interesting tool in molecular oncology due to its sensitivity, simplicity, low cost or rapid times of measurement. However, majority of EC assays, same as most optical-based techniques, require preceding DNA extraction step to remove other cellular components, making these assays more laborious and time-consuming. One option to circumvent this is to use LAMP (loop-mediated amplification), an isothermal amplification technique that can amplify DNA directly in crude lysates in a short time at a constant temperature.

DNA Methylation in Solid Tumors: Functions and Methods of Detection.

DNA methylation, i.e., addition of methyl group to 5'-carbon of cytosine residues in CpG dinucleotides, is an important epigenetic modification regulating gene expression, and thus implied in many cellular processes.

Influence of Protein Modification and Glycosylation in the Catalytic Hydrogen Evolution Reaction of Avidin and Neutravidin: An Electrochemical Analysis.

To investigate glycans' influence on the behavior of glycoproteins on charged surfaces, avidin and its nonglycosylated and neutralized version neutravidin were studied by label-free chronopotentiometric stripping (CPS) analysis and alternating current voltammetry combined with a mercury electrode. Despite neutravidin's and avidin's similar size and structure, their CPS responses differed due to the different amounts of catalytically active free amino groups of lysine and arginine residues. Acetylation of the proteins resulted in the suppression of their CPS responses by almost four times for avidin and by about 50 % for neutravidin, respectively.

Prevalence of common MEFV mutations and carrier frequencies in a large cohort of Iranian populations.

Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder caused by mutations in the MEFV gene. The disease is especially common among Armenian, Turkish, Jewish and Middle East Arab populations. To identify the frequency and the spectrum of common MEFV mutations in different Iranian populations, we investigated a cohort of 208 unselected asymptomatic individuals and 743 FMF patients.