Vancomycin-Loaded FeO/MOF-199 Core/Shell Cargo Encapsulated by Guanidylated-β-Cyclodextrine: An Effective Antimicrobial Nanotherapeutic.

This study describes an efficient antimicrobial drug delivery system composed of iron oxide magnetic nanoparticles (FeO NPs) coated by an MOF-199 network. Then, the prepared vancomycin (VAN)-loaded carrier was fully packed in a lattice of beta-cyclodextrin (BCD). For cell adhesion, beta-cyclodextrin has been functionalized with guanidine (Gn) groups within in situ synthetic processes.