Fabrication and characteristics of new quaternized chitosan nanocapsules loaded with thymol or thyme essential oil as effective SARS-CoV-2 inhibitors.

This research explores the potential of encapsulating thyme essential oil (TEO) and thymol (TH) into quaternized chitosan nanocapsules to combat SARS-CoV-2. Initially, the bioactive materials, TH and TEO, were extracted from and then structurally and phytochemically characterized by spectral and GC-MS analyses. Meanwhile, -quaternized ultrasonic-mediated deacetylated chitosan (QUCS) was successfully synthesized and characterized.

Anti-Covid-19 Drug Analogues: Synthesis of Novel Pyrimidine Thioglycosides as Antiviral Agents Against SARS-COV-2 and Avian Influenza H5N1 Viruses.

A class of pyrimidine thioglycoside analogs () were synthesized from a reaction of 2-cyano-3,3-dimercapto--arylacrylamide () and thiourea to produce the corresponding 4-amino-2-mercapto--arylpyrimidine-5-carboxamide derivatives (), and stirring of compounds () with peracylated α-d-- and galacto-pyranosyl bromides () in DMF-sodium hydride gave the corresponding pyrimidine thioglycosides () Deacetylation of the pyrimidine thioglycosides via a reaction with dry NH/MeOH gave the corresponding free pyrimidine thioglycosides () The compounds have been characterized by C NMR, H NMR, and IR. Pharmacological evaluation of compounds , , and in vitro against SARS-COV-2 and Avian Influenza H5N1 virus strains revealed that some compounds possess interesting activity.

Synthesis of novel pyrimidine thioglycosides as structural analogs of favipiravir (avigan) and their antibird flu virus activity.

Novel class of amino pyrimidine thioglycoside derivatives were designed from sodium 2-cyano-3-(arylamino)prop-1-ene-1,1-bis(thiolate) and guanidine hydrochloride to afford the corresponding sodium 2,6-diamino-5-aryl-1,2-dihydropyrimidine-4-thiolate , which in coupling with peracylated -D-gluco- and galactopyranosyl bromides in DMF gave the corresponding pyrimidine thioglycosides . Acidification of 2,6-diamino-5-aryl-1,2-dihydropyrimidine-4-thiolate salts with hydrochloric acid formed the corresponding pyrimidine-4-thioles . The latter were stirred with peracetylated halo sugars α-D-gluco- and galacto-pyranosyl bromides in sodium hydride and DMF to yield the pyrimidine thioglycosides .

Toward Developing Therapies against Corona Virus: Synthesis and Anti-Avian Influenza Virus Activity of Novel Cytosine Thioglycoside Analogues.

A series of pyrimidine and pyrimidine thioglycoside derivatives were newly synthesized using sodium 2-cyano-3-(arylamino)prop-1-ene-1,1-bis(thiolates) and urea to give the corresponding sodium 6-amino-5-aryl-2-oxo-1,2-dihydropyrimidine-4-thiolates. Stirring of the latter with peracetylated α-d-gluco- and galacto-pyranosyl bromides in DMF afforded the corresponding pyrimidine thioglycosides. On the other hand, treatment of 6-amino-5-aryl-2-oxo-1,2-dihydropyrimidine-4-thiolate salts with hydrochloric acid produced the corresponding pyrimidine-4-thioles, which on stirring with α-d-gluco- and galacto-pyranosyl bromides in sodium hydride and DMF gave the corresponding pyrimidine thioglycosides.