Curious neurologic sequelae in galactosemia.

Two siblings with classic transferase deficiency galactosemia that was detected at birth have been treated with lactose restriction since the neonatal period. Both patients developed a unique and progressive neurologic syndrome of mental retardation, tremor, and ataxia. Careful review of the family history and medical records, the absence of metabolic disturbances other than those related to galactosemia, and the aggregate physical findings and neurodiagnostic studies ruled out other neurologic disorders in these siblings.

Taste preference of the adult rat as a function of prenatal exposure to ethanol.

Two groups of pregnant rats (n = 10) received exposure to either 10% ethanol or water. All male offspring (n = 43) received a six-day preference test (ethanol vs water) at 90 days of age. Fluid consumption scores indicated a significant preference for water by all Ss.

Hypoxanthine-guanine phosphoribosyltransferase in human erythroid cells: properties of the isozymes.

We have previously given evidence that the hypoxanthine-guanine phosphoribosyltransferase (HGPRT; EC 2.4.2.

Identifying and tracing a population at risk: the DESAD Project experience.

In recent years, medical record review has been used to alert patients who have received drugs or treatments that have newly discovered side-effects. The experience of the national cooperative Diethylstilbestrol-Adenosis (DESAD) Project in identifying and notifying women exposed in utero to diethylstilbestrol (DES) shows this to be a difficult task. In order to identify 4,830 exposed women, 221,245 charts were reviewed.

An influenza virus matrix protein-specific human T cell line with helper activity for in vitro anti-hemagglutinin antibody production.

A human helper T cell line (F14m) activated by the matrix protein purified from A/X31 influenza virus has been developed. After activation by antigen for 7 days, and reculture with matrix protein and irradiated autologous feeder cells, the cells obtained from an in vivo influenza virus-immunized donor have been growing in the presence of interleukin 2 for more than 7 months. The cells all belong to the helper-inducer T cell subset and most of them express surface membrane HLA-DR antigens.

Dietary obesity in adult and weanling rats following removal of interscapular brown adipose tissue.

In order to investigate the role of brown adipose tissue (BAT) in diet-induced thermogenesis (DIT), a selection of palatable, energy-dense foods (Cafeteria diet) was used to increase the energy intakes of adult and weanling male rats, from some of which interscapular BAT (IBAT) had been surgically excised. Removal of IBAT had no effect upon energy intakes of the cafeteria-fed rats, nor of controls fed a pelleted stock diet. The rate of weight gain of intact controls was similar for the two diets, but adults with IBAT removed and fed with the cafeteria diet gained weight more rapidly than those fed the stock diet.

Sex role concepts of two- and three-year-olds.

An instrument was developed to assess beliefs about males and females in very young children. Use of the instrument with 72 2- and 3-year-old subjects indicated that children as young as 2 years of age possess substantial knowledge of sex role stereotypes prevailing in the adult culture. Knowledge of sex role stereotypes was highly correlated (.

A study of pesticide residues in Michigan's general population, 1968-70.

A study undertaken in Michigan from August 1968 to April 1970 showed that the county of residence was the most significant factor for determining pesticide residue levels in humans. Occupation, sex, and location of residence were also determined to be associated with blood residue levels. Residues of sigmaDDT and dieldrin were greater in persons 45 years or older.

Synthesis of 2,3-dinor-PGFalpha metabolites.

This report describes the preparation of various 2,3-dinor-PGFalpha prostaglandins. Of particular importance is the synthesis of 2,3-dinor-15(S)-15-methyl PGF2alpha, the primary metabolite in the enzymatic degradation of 15(S)-15-methyl-PGF2alpha (1). Introduction of the three carbon beta,gamma-unsaturated carboxyl side chain was achieved in a one-step Wittig reaction.

The Erysichthon syndrome. Progression of coronary atherosclerosis and dietary hyperlipidemia.

One hundred nineteen patients with coronary artery disease confirmed by coronary arteriograms were studied. Cine coronary arteriography confirmed progression of atherosclerosis in 106 (89%) patients (mean age 50.9 yr) and nonprogression in 13 (11%) patients (mean age 50.

Alpha-fetoprotein in fetal skin and muscle.

The skin and muscles of human fetuses were used to obtain extracts of alpha-fetoprotein (AFP). Fetuses up to sixteen weeks gestation gave the highest yields. Rabbits immunized by concentrates from this source made anti-AFP of a quality suitable for use in radioimmunoassay systems.