Publications by authors named "Naser Kakavandi"
Article Synopsis
- * Enzymes are categorized into six classes based on their functions and mechanisms, and they have diverse applications in medicine, including treatments for inflammation and digestion.
- * The review discusses the growing significance of bacterial enzymes in various industries and highlights the necessity for optimizing their production and extraction to meet rising demand while addressing challenges like immunogenicity and short half-life.
Article Synopsis
- The study examines how inflammatory processes involving prostaglandins could influence the narrowing of blood vessels (stenosis) in patients with coronary artery issues.
- Researchers focused on measuring specific gene expressions linked to PGE2 metabolism, in addition to assessing the impact of certain microRNAs (miR-520, miR-1297, and miR-34) on these gene expressions.
- Findings showed a significant increase in gene expression and serum levels related to PGE2 metabolism among patients, highlighting the potential role of miR-34 and miR-520 in the synthesis pathway affecting patients with and without stent restenosis.
Kawasaki disease (KD) has been declared a rare idiopathic condition for a long time. The children age less than five years, as the most susceptible group, are at risk of this disease. Since the cause of the disease is unknown, this study was designed to investigate the cause of KD.
View Article and Find Full Text PDFCOX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis.
Endocr Metab Immune Disord Drug Targets
September 2021
Background: The vessel restenosis is related to the inflammatory events in subendothelial space. It is proposed that the inflammatory agents affect the prostaglandin synthesis pathway. In this study, we investigated the COX-1, COX-2, PTGDS and miRNA-520a-5p expression levels and the serum 15-Deoxy-Δ-PGJ2 metabolite values in patients with the stenosed and re-stenosed vessels.
View Article and Find Full Text PDFBackground: The integrin family receptors stimulate the cellular proliferation and migration through the focal adhesion pathway by the activation of PTK2, VASP and TSP1 proteins. The purpose of this study was to investigate the integrin-ligated motifs through the activation of focal adhesion pathway.
Methods: A chimeric peptide was predicted from the integrin-mediated ligands by bioinformatics tools.
Background: The Matrix Metalloproteinase (MMPs) secreted from macrophages can affect the extracellular matrix remodeling process and improve varicose veins.
Aim: The aim of this study was to investigate the MMP-2 and MMP-9 gene expression and activity levels in the differentiated macrophages M2 of subjects with varicose veins, and to evaluate a peptide construct on their catalytic functions.
Methods: The macrophages were differentiated from the monocytes using M-CSF.
Association Between Fat-soluble Vitamins and Lipid Profile in the Overweight Population.
Recent Pat Food Nutr Agric
March 2021
Background & Aims: It is well-known that the coronary artery stenosis is related to lipid profile. This is a descriptive cross-sectional study to investigate the relationship between the serum fat-soluble vitamins (A, E and D), circulating proprotein convertase subtilisin/kexin type 9 (PCSK9), and lipid profile in the study population.
Methods: A total of 120 overweight subjects were participated in this study.