Publications by authors named "Naseem Zomorodi"
Due to extensive connectivity of the parietal lobe, non-lesional drug-resistant (DRE) parietal lobe epilepsies (PLEs) are difficult to localize and often imitate other epilepsies. Therefore, patients with PLEs have low rates of seizure freedom following epilepsy surgery. Previous studies have highlighted the need to combine EEG and semiology for more accurate localization of PLEs.
View Article and Find Full Text PDFDalfampridine is a drug used to improve walking in multiple sclerosis (MS) patients. Approved in 2010, it is contraindicated in patients who have a history of seizures and/or renal disease. In this case report, we present a patient who did not have either of these contraindications yet had a seizure episode with the only contributing factor being the use of dalfampridine.
View Article and Find Full Text PDFArticle Synopsis
- Multiple sclerosis (MS) is an autoimmune disorder that leads to increased inflammation and disrupts the blood-brain barrier, driving the need for affordable and reliable biomarkers to monitor the disease.
- The study involved relapsing-remitting MS patients who provided blood samples to analyze levels of certain cytokines, opioid peptides, and complete the MSQOL-54 survey to assess quality of life.
- Results indicated that serum levels of Opioid Growth Factor (OGF) and β-endorphin were elevated in MS patients compared to healthy individuals, with potential correlations between these biomarkers and measures of physical health, suggesting their viability for tracking disease status.
17β-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner.
Am J Physiol Lung Cell Mol Physiol
November 2019
Inflammatory lung diseases affect men and women disproportionately, suggesting that fluctuations of circulating hormone levels mediate inflammatory responses. Studies have shown that ozone exposure contributes to lung injury and impairment of innate immunity with differential effects in men and women. Here, we hypothesized that 17β-estradiol enhances inflammation and airway hyperresponsiveness (AHR), triggered by ozone exposure, in the female lung.
View Article and Find Full Text PDFRole of transplanted bone marrow cells in development of rotator cuff muscle fatty degeneration in mice.
J Shoulder Elbow Surg
December 2017
Background: Rotator cuff muscle fatty degeneration after a chronic tendon tear is an irreversible pathologic change associated with poor clinical outcomes of tendon repair, and its exact pathogenesis remains unknown. We sought to investigate the role of transplanted bone marrow cells in the development of fatty degeneration, specifically in adipocyte accumulation, using a mouse model.
Methods: Fourteen mice were divided into 2 bone marrow chimeric animal groups: bone marrow transplantation (BMT) group and reverse BMT group.