Publications by authors named "Narvaez J"

To investigate the prevalence and clinical spectrum of atypical or non-classical complications in adult-onset Still's disease (AOSD) beyond macrophage activation syndrome (MAS) and to identify factors linked to their occurrence. Multicenter cross-sectional study of AODS cases included in the Spanish registry on Still's disease. This study included 107 patients (67% women), of whom 64 (59.

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Objective: To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs).

Methods: Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent.

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Objectives: To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality.

Methods: ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively.

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Objective: To investigate differences in arterial involvement patterns on F-FDG PET-CT between predominant cranial and isolated extracranial phenotypes of giant cell arteritis (GCA).

Methods: A retrospective review of F-FDG PET-CT findings was conducted on 140 patients with confirmed GCA. The patients were divided into two groups: the cranial group, which presented craniofacial ischemic symptoms either at diagnosis or during follow-up, and the isolated extracranial group which never exhibited such manifestations.

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Background: Substance Use Disorders are often associated with significant levels of domestic and external violence registered among abusers. This investigation aimed to evaluate the Domestic Violence Involvement (DVI) and related gender differences among Crack Cocaine Users in Brazil.

Methods: For this purpose, a secondary data analysis of a multicenter cross-sectional study involving 780 Crack Cocaine Users from 6 Brazilian capitals was performed.

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: Interstitial lung disease (ILD) is one of the most severe complications of rheumatoid arthritis (RA). Real-world data on antifibrotic treatment are needed. Our objective was to evaluate the real-world effectiveness and tolerability of antifibrotic agents in patients with progressive fibrosing RA-ILD.

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Background: In low- and middle-income countries (LMICs), laparoscopic surgery is challenging to implement due to limited resources and lack of expert surgeons as teachers. The Global Laparoscopic Advancement Program (GLAP) was developed by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) to deliver sustainable and effective methods for teaching safe laparoscopic surgery. GLAP aims to train surgical leaders and trainees with the goal of eventual in-country replication of GLAP programming.

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This dataset was collected during the 2023 and 2024 RoboCup competitions using the TIAGo robot equipped with an RGB-D camera, a Hokuyo laser, and a RODE microphone. The dataset includes ROSbag files that capture the robot's sensory data and planning task behavior, as well as video recordings that provide third-person perspectives of task execution. These data provide information about the performance of autonomous robots in social tasks and navigation in dynamic environments with human interaction.

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Objetive: To evaluate the frequency and timing of sustained drug-free remission (SDFR) in patients with giant cell arteritis (GCA) and to identify potential predictive factors of this outcome.

Methods: Retrospective review of all patients included in the large Spanish multicentre registry for GCA (ARTESER) with at least two years of follow-up. SDFR was defined as the absence of typical signs, symptoms, or other features of active GCA for ≥12 months after discontinuation of treatment.

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Article Synopsis
  • Giant cell arteritis (GCA) is a complex disease with various symptoms and severity levels, and the study aimed to evaluate its different clinical subsets to improve treatment strategies and reduce complications.
  • The study categorized GCA into three phenotypes: cranial, extracranial, and occult, analyzing their association with severe complications and survival rates over time.
  • Results indicated that cranial GCA had more severe ischemic complications and visual disturbances, while the occult subset showed potential for higher mortality, highlighting the need for targeted treatment approaches based on these clinical patterns.
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  • The study investigates the link between antiphospholipid antibodies (aPL) and diffuse alveolar hemorrhage (DAH) in patients with systemic lupus erythematosus (SLE) through a systematic review and meta-analysis.
  • Out of 454 studies reviewed, 9 were included, showing that SLE patients with positive aPL, especially lupus anticoagulant and anticardiolipin IgG, are more likely to experience DAH.
  • Additionally, having antiphospholipid syndrome (APS) increases the risk of DAH significantly compared to patients without APS.
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Imaging studies have transformed the diagnosis of large vessel vasculitis (LVV) involvement in giant cell arteritis (GCA). A positron emission tomography/computed tomography (PET/CT) scan with 18-fluorodeoxyglucose (18F-FDG) has emerged as a valuable tool for assessing LVV. We aimed to determine the utility of an 18F-FDG-PET/CT scan in detecting LVV in GCA in the ARTESER registry.

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Solitary Rectal Ulcer Syndrome (SRUS) is a rare defecation disorder with varied clinical manifestations and often presents challenges in diagnosis. To date, there is no definitive treatment for SRUS. However, there is consensus that treatment should be individualized, multimodal, and focused on addressing potential causes of the disease.

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Article Synopsis
  • The article discusses corrections to research findings initially published.
  • It emphasizes the importance of accuracy in scientific communication.
  • This correction aims to ensure that readers are aware of any significant changes to the original data and conclusions.
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Patients with rheumatoid arthritis (RA) are at increased risk of developing interstitial lung disease compared to the general population, a complication that is associated with significant morbidity and high mortality. Given its frequency and severity, ILD should always be considered during both the initial assessment and follow-up of RA patients. However, there is currently no consensus on which RA patients should be screened for ILD.

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To describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a diagnosis or suspected diagnosis of sJIA or AOSD according to the responsible physician and followed-up for at least one year.

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Article Synopsis
  • The study examined the effectiveness and safety of Janus kinase inhibitors (JAKi) for treating rheumatoid arthritis-associated interstitial lung disease (RA-ILD), an area with limited therapeutic options.
  • It included a systematic review of literature and meta-analysis of data from seven observational studies and found that JAKi improved lung function and imaging results in patients with RA-ILD.
  • The results indicated that JAKi were generally well tolerated, with a low risk of developing new ILD, and showed similar safety and efficacy to existing treatments like abatacept and rituximab.
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Background: Long-term deterioration in the mental health of healthcare workers (HCWs) has been reported during and after the COVID-19 pandemic. Determining the impact of COVID-19 incidence and mortality rates on the mental health of HCWs is essential to prepare for potential new pandemics. This study aimed to investigate the association of COVID-19 incidence and mortality rates with depressive symptoms over 2 years among HCWs in 20 countries during and after the COVID-19 pandemic.

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Article Synopsis
  • Non-infectious inflammatory ocular diseases can be challenging to diagnose and manage, often requiring systemic immunosuppressive therapy; JAK inhibitors may offer a new treatment approach.
  • A study with 12 patients showed that systemic diseases were present in 67% of cases, and various JAK inhibitors were administered, with an average treatment duration of 8.6 months.
  • Results indicated complete ocular disease control in all patients after treatment, with a significant reduction in the incidence of ocular flares, confirming the efficacy and safety of JAK inhibitors for these conditions.
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Introduction: Data on prevalence of fatigue in rheumatoid arthritis (RA) patients in the era of biological treatments remains scarce, with a lack of case-control studies. This study evaluates the prevalence of fatigue in Spanish women over 50 years with RA using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale, explores its association with RA-related variables, and seeks to identify the primary factors influencing fatigue. Ultimately, our objective is to underscore the clinical significance of fatigue as a comorbidity and to advocate for its systematic evaluation in routine clinical practice.

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Objective: To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort.

Methods: Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI).

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Article Synopsis
  • * Out of 196 patients treated with TCZ, a significant percentage achieved clinical remission within six months, but imaging improvements lagged behind, with only 12% showing imaging remission at that time.
  • * Despite initial concerns, no new aneurysms developed in patients on TCZ therapy during the follow-up, indicating its potential as a safe treatment option for GCA-aortitis.
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Objective: To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase syndrome and progressive interstitial lung disease (ASS-ILD).

Methods: Multicentre observational retrospective longitudinal study of a cohort of patients with ASS-ILD that started treatment with RTX due to recurrent or ongoing progressive ILD despite therapy with glucocorticoids and immunosuppressants.

Results: Twenty-eight patients were analyzed.

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