Leveraging machine learning to study how temperament scores predict pre-term birth status.

Background: Preterm birth (birth at <37 completed weeks gestation) is a significant public heatlh concern worldwide. Important health, and developmental consequences of preterm birth include altered temperament development, with greater dysregulation and distress proneness.

Aims: The present study leveraged advanced quantitative techniques, namely machine learning approaches, to discern the contribution of narrowly defined and broadband temperament dimensions to birth status classification (full-term vs.

Pneumatic Bellow Actuator with Embedded Sensor Using Conductive Carbon Grease.

The present work demonstrates the manufacturing process of a pneumatic bellow actuator with an embedded sensor, utilizing a novel manufacturing approach through the complete use of additive manufacturing techniques, such as direct ink writing (DIW) and traditional fused deposition modeling (FDM) methods. This study is innovative in its integration of a dielectric electroactive polymer (DEAP) structure with sensing electrodes made of conductive carbon grease (CCG), showcasing a unique application of a 3D-printed DEAP with CCG electrodes for combined DEAP sensing and pneumatic actuation. Initial experiments, supported by computational simulations, evaluated the distinct functionality of the DEAP sensor by itself under various pressure conditions.

Humanity's evolved nest and its relation to cardiac vagal regulation in the first years of life.

Background: The Evolved Developmental Niche (EDN) is a millions-year-old developmental system that matches the maturational schedule of the offspring, optimizing health. Every animal has a developmental niche.

Aims: Humanity has fallen away from providing its EDN.

Early-life external exposome in children 2-5 years old in Colombia.

Exposome studies are advancing in high-income countries to understand how multiple environmental exposures impact health. However, there is a significant research gap in low- and middle-income and tropical countries. We aimed to describe the spatiotemporal variation of the external exposome, its correlation structure between and within exposure groups, and its dimensionality.

The role of modern parameters and their relationship with recurrence risk as assessed by Oncotype DX: real-world evidence.

Genomic analysis through various platforms is an essential tool for determining prognosis and treatment in a significant subgroup of early-stage breast cancer patients with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative status. Additionally, combined clinical and pathological characteristics can accurately predict the recurrence score (RS), as demonstrated by the University of Tennessee risk nomogram. In this study, we aimed to identify classical clinical-pathological factors associated with high RS in a local population, including modern parameters such as current abemaciclib treatment recommendations, HER2-low status, different Ki-67 cutoff values, and samples obtained from secondary primary tumours.

The Emerging Role of Tertiary Lymphoid Structures in Breast Cancer: A Narrative Review.

This narrative review aims to clarify the role of tertiary lymphoid structures in breast cancer. We examine their development, composition, and prognostic value, and current ways of recognizing them. A comprehensive literature review was performed using the PubMed/Medline, Scopus, and EMBASE databases.

The evolved nest, oxytocin functioning, and prosocial development.

Prosociality, orientation to attuned, empathic relationships, is built from the ground up, through supportive care in early life that fosters healthy neurobiological structures that shape behavior. Numerous social and environmental factors within early life have been identified as critical variables influencing child physiological and psychological outcomes indicating a growing need to synthesize which factors are the most influential. To address this gap, we examined the influence of early life experiences according to the evolved developmental niche or and its influence on child neurobiological and sociomoral outcomes, specifically, the oxytocinergic system and prosociality, respectively.

Cytotoxic Evaluation in HaCaT Cells of the Pa.7 Bacteriophage from () , Free and Encapsulated Within Liposomes.

Introduction: Acne is a multifactorial disease involving the colonization of skin follicles by (formerly ) . A combination of different retinoid-derived products, antibiotics, and hormonal antiandrogens are used to treat the disease, but these treatments require extended periods, may have secondary effects, are expensive, and not always effective. Owing to antibiotic resistance, the use of bacteriophages has been proposed as an alternative treatment.

Aerobic bacteria produce nitric oxide via denitrification and promote algal population collapse.

Microbial interactions govern marine biogeochemistry. These interactions are generally considered to rely on exchange of organic molecules. Here we report on a novel inorganic route of microbial communication, showing that algal-bacterial interactions between Phaeobacter inhibens bacteria and Gephyrocapsa huxleyi algae are mediated through inorganic nitrogen exchange.

Microbially Synthesized Polymer-Metal Nanoparticles Composites as Promising Wound Dressings to Overcome Methicillin-Resistance Infections.

Antimicrobial resistance has been declared one of the top 10 global public health threats. Methicillin-resistant (MRSA) is a leading cause of recurring skin and soft tissue infections in patients with chronic skin conditions such as diabetic foot infections, making the treatment of the ulcers challenging. Wound dressings combined with metal nanoparticles have been suggested to prevent and treat MRSA-infected wounds.

Case Report: Desmoid fibromatosis in the mediastinum of a 6-month-old toddler, what to do?

Desmoid fibromatosis is a rare, aggressive borderline lesion arising from soft tissues. Treatment will depend on the structures that the tumor has involved. Surgery with negative margins is the recommended strategy as it can usually achieve disease control; however, the tumor's location sometimes does not allow it.

Characterization of the external exposome and its contribution to the clinical respiratory and early biological effects in children: The PROMESA cohort study protocol.

Background: Air pollution contains a mixture of different pollutants from multiple sources. However, the interaction of these pollutants with other environmental exposures, as well as their harmful effects on children under five in tropical countries, is not well known.

Objective: This study aims to characterize the external exposome (ambient and indoor exposures) and its contribution to clinical respiratory and early biological effects in children.

Improving planetary health is integral to improving children's health-a call to action.

This article summarizes the adverse effects of climate and environmental change on children's health. We call for policy change, education, and advocacy to halt further deterioration of planetary health and for specific measures to prevent the negative effects of climate and environmental change on children's health. We offer an agenda for research, policy change, and healthcare practices to improve the resilience of pediatric populations in the face of climate change.

Association of buccal micronucleus cytome assay (BMNCyt) biomarkers with inorganic element concentration and genetic polymorphisms in welders.

Welding fumes are classified as carcinogenic to humans. The aim of the present study was to measure buccal micronucleus cytome assay biomarkers and to evaluate their association with inorganic elements and genetic polymorphisms (XRCC1, OGG1, XRCC3, GSTM1, and GSTT1) in welders (n = 98) and control individuals (n = 100). Higher levels of DNA damage and cell death were observed in the exposed group.

Precision medicine in the real-world setting. Clinical activity of talazoparib in a woman with hormone receptor-positive HER2-negative metastatic breast cancer with pathogenic mutation in somatic BRCA2.

Background: Next-generation sequencing (NGS) has proven to be a key implementation to understanding biological pathways involved in cancer. In daily practice, the identification of somatic and germline mutations has allowed physicians to gather relevant information to make therapeutic decisions and benefit patients. Importantly, somatic mutations provide targeted opportunities for treatment and reveal resistance mechanisms to understand patients' tumour evolution.

How deep do we have to go to rehabilitate evolutionary psychology? Reply to Bjorklund et al. (2022).

Disciplines like evolutionary developmental psychology admirably focus on trying to rehabilitate narrow evolutionary psychology (NEP) from within, by adding a developmental focus to NEP's tenets of adaptationism and computationalism. We argue, however, that these tenets are fundamentally incompatible with taking psychology and its development seriously, and that the kinds of modifications introduced by evolutionary developmental psychologists do not go deep enough to qualitatively change the nondevelopmental outlook of NEP. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Sociomoral Temperament: A Mediator Between Wellbeing and Social Outcomes in Young Children.

Social outcomes, such as empathy, conscience, and behavioral self-regulation, might require a baseline of psychological wellbeing. According to Triune Ethics Metatheory (TEM), early experience influences the neuropsychology underlying a child's orientation toward the social and moral world. Theoretically, a child's wellbeing, fostered through early caregiving, promotes sociomoral temperaments that correspond to the child's experience, such as social approach or withdrawal in face-to-face situations.

Evolving evolutionary psychology.

Which evolutionary theory can best benefit psychological theory, research, and application? The most well-known school of evolutionary psychology has a narrow conceptual perspective (a.k.a.

Effects of adverse childhood experience on physiological regulation are moderated by evolved developmental niche history.

Childhood experiences of early life stress and adversity can lead to long-term detrimental outcomes across the lifespan. Recent evidence suggests avoiding stressors is not enough for species-typical development. Nurturing and responsive care are needed to both buffer adverse experiences as well as promote healthy development, but little is known regarding the interaction between species-typical environmental support in childhood, Evolved Developmental Niche history (EDN-history), and adversity on physiological regulation in adult women.

Opportunities for free play and young children's autonomic regulation.

Aspects of the social environment have been linked to the physiological mechanisms underlying behavioral self-regulation. Play, a behavior connected to regulatory behaviors such as delay of gratification and regulation of emotions, might be an aspect of social environments that is supportive of healthy physiological adaptation. We examined whether opportunities for social free play with peers, as reported by mothers, would predict children's autonomic regulation (via respiratory sinus arrhythmia; RSA) in a sample of 78 five-year-old children.

Trolley dilemma in the sky: Context matters when civilians and cadets make remotely piloted aircraft decisions.

Crews operating remotely piloted aircrafts (RPAs) in military operations may be among the few that truly experience tragic dilemmas similar to the famous Trolley Problem. In order to analyze decision-making and emotional conflict of RPA operators within Trolley-Problem-like dilemma situations, we created an RPA simulation that varied mission contexts (firefighter, military and surveillance as a control condition) and the social "value" of a potential victim. We found that participants (Air Force cadets and civilian students) were less likely to make the common utilitarian choice (sacrificing one to save five), when the value of the one increased, especially in the military context.

Cytokinesis-block micronucleus cytome (CBMN-CYT) assay biomarkers and telomere length analysis in relation to inorganic elements in individuals exposed to welding fumes.

During the welding activities many compounds are released, several of these cause oxidative stress and inflammation and some are considered carcinogenic, in fact the International Agency for Research on Cancer established that welding fumes are carcinogenic to humans. The aim of the present study was to analyze the cytotoxic and genotoxic potential of exposure to welding fumes and to determine concentrations of metals in blood and urine of occupationally exposed workers. We included 98 welders and 100 non-exposed individuals.

Novel complexes with ONNO tetradentate coumarin schiff-base donor ligands: x-ray structures, DFT calculations, molecular dynamics and potential anticarcinogenic activity.

The synthesis of eight novel Zn(II), Co(II), Cu(II), Ni(II) and Pt(II) complexes (2-9) derived from the ONNO tetradentate coumarin Schiff-Base donor ligands, L and the novel L, was performed. All compounds were characterized by analytical, spectrometry and spectroscopy techniques. Complexes 2-4 were also characterized by DFT calculations and the structures of 5 and 6 were determined by single-crystal X-ray diffraction analysis.