Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels.

Albumin-based hydrogels offer unique benefits such as biodegradability and high binding affinity to various biomolecules, which make them suitable candidates for biomedical applications. Here, we report a non-immunogenic photocurable human serum-based (HSA) hydrogel synthesized by methacryloylation of human serum albumin by methacrylic anhydride (MAA). We used matrix-assisted laser desorption ionization-time-of-flight mass spectrometry, liquid chromatography-tandem mass spectrometry, as well as size exclusion chromatography to evaluate the extent of modification, hydrolytic and enzymatic degradation of methacrylated albumin macromer and its cross-linked hydrogels.

Enrichment of bovine X-sperm using microfluidic dielectrophoretic chip: A proof-of- concept study.

The microfluidic dielectrophoretic (MF-DEP) chip is a new, economical and readily-available technology that might be used to enrich X-sperm for increasing female offspring in dairy farms. In this study, we sought to develop an MF-DEP chip to enrich X bovine sperm. The MF-DEP chip was composed of an electrode attached to a glass slide and a microchannel made from polydimethylsiloxane.

Mapping the heterogeneity of protein corona by ex vivo magnetic levitation.

In the past decade, we witnessed limited success in the clinical translation of therapeutic nanoparticles (NPs). One of the main reasons for this limited success is our poor understanding of the biological identity of NPs. Herein, we report magnetic levitation (MagLev) as a complementary analytical tool to investigate the homogeneity of the created protein corona (PC) coated NPs through an ex vivo model.

pH-Sensitive Polymer Conjugates for Anticorrosion and Corrosion Sensing.

In 2015, the global cost of corrosion in the world was estimated to be around 2.5 trillion dollars and has been continuously increasing. The active protection by corrosion inhibitors is a well-known technique for protecting metals against corrosion.

Redox-Responsive Polymer with Self-Immolative Linkers for the Release of Payloads.

Previous couplings of corrosion inhibitors to redox-responsive polymers via covalent bonding suffer from several drawbacks. It is presented here novel redox-responsive polymer-corrosion inhibitor conjugates that contain self-immolative linkers in their side chains. Very fast redox-induced release of tryptamine, a drug and a corrosion inhibitor, is observed after applying a reductive trigger.