A Case of 5-Fluorouracil-Induced Hyperammonemia and Lactic Acidosis Successfully Treated With Continuous Hemodiafiltration Dialysis.

A 51-year-old male patient with stage IVc upper rectal cancer received treatment with aflibercept beta and folinic acid, fluorouracil, and irinotecan. Two days following treatment, he presented with an altered mental status. Head computed tomography showed no abnormalities, but blood tests revealed hyperammonemia and lactic acidosis.

Pre-Admission Predictors of Walking Independence in Critically Ill Patients.

Background: Recovery of walking independence in critically ill patients is required for safe discharge home. However, the pre-admission predictors affecting this outcome in this patient group are unknown. This study aimed to identify these predictors.

A retrospective study of in-hospital cardiac arrest.

Aim: In-hospital cardiac arrest is an important issue in health care today. Data regarding in-hospital cardiac arrest in Japan is limited. In Australia and the USA, the Rapid Response System has been implemented in many institutions and data regarding in-hospital cardiac arrest are collected to evaluate the efficacy of the Rapid Response System.

Hepatocyte growth factor enhances the barrier function in primary cultures of rat brain microvascular endothelial cells.

The effects of hepatocyte growth factor (HGF) on barrier functions were investigated by a blood-brain barrier (BBB) in vitro model comprising a primary culture of rat brain capillary endothelial cells (RBEC). In order to examine the response of the peripheral endothelial cells to HGF, human umbilical vascular endothelial cells (HUVEC) and human dermal microvascular endothelial cells (HMVEC) were also treated with HGF. HGF decreased the permeability of RBEC to sodium fluorescein and Evans blue albumin, and dose-dependently increased transendothelial electrical resistance (TEER) in RBEC.