In Vitro Sensitivity of Pyronaridine in Thai Isolates of .

Pyronaridine, a Mannich base antimalarial agent with a high activity against chloroquine-resistant , has been combined with artesunate as a new artemisinin based combination therapy (ACT). Pyronaridine-artesunate combination could be one of the choices for the treatment of uncomplicated falciparum malaria in multidrug-resistant areas including Thailand. The aim of this study was to determine in vitro sensitivity and cross-resistance pattern of pyronaridine in Thai isolates of .