Publications by authors named "Naruemon Klaikaew"
Article Synopsis
- Guidelines suggest that patients with high-risk gastric intestinal metaplasia should have endoscopic surveillance for gastric cancer every three years.
- This study explored the effectiveness of radiofrequency ablation (RFA) in completely eliminating high-risk gastric intestinal metaplasia.
- Results showed that RFA led to a significantly higher complete resolution rate of GIM lesions compared to a group receiving only observation, particularly in those with incomplete GIM.
Article Synopsis
- The study examines the diagnostic performance of general gastroenterologists (GEs) in identifying gastric intestinal metaplasia (GIM) using narrow-band imaging (NBI), comparing them to experts in the field (XPs).
- Results showed that GEs had lower specificity and accuracy in GIM diagnosis than XPs, with GEs achieving a sensitivity of 91% and an accuracy of 83%, compared to XPs' 93% and 88%, respectively.
- For GEs to reach diagnostic accuracy of 80% or higher, they need to evaluate at least 100 lesions, indicating a learning curve in their proficiency with NBI-guided diagnoses.
Background/aims: Previous artificial intelligence (AI) models attempting to segment gastric intestinal metaplasia (GIM) areas have failed to be deployed in real-time endoscopy due to their slow inference speeds. Here, we propose a new GIM segmentation AI model with inference speeds faster than 25 frames per second that maintains a high level of accuracy.
Methods: Investigators from Chulalongkorn University obtained 802 histological-proven GIM images for AI model training.
Article Synopsis
- Recent guidelines recommend at least five biopsies for gastric intestinal metaplasia (GIM) diagnosis, but NBI-targeted biopsies may suffice for identifying extensive GIM.
- A study involving 95 GIM patients compared NBI-targeted biopsies to the Sydney protocol, finding NBI had slightly lower sensitivity and accuracy but required significantly fewer samples (311 vs. 475).
- Both biopsy methods achieved over 90% negative predictive value, suggesting that NBI-targeted biopsies are a viable and less invasive alternative for diagnosing extensive GIM.
Background: Diagnostic laparoscopy is often a necessary, albeit invasive, procedure to help resolve undiagnosed peritoneal diseases. Previous retrospective studies reported that EUS-FNA is feasible on peritoneal and omental lesions, however, EUS-FNA provided a limited amount of tissue for immunohistochemistry stain (IHC).
Aim: This pilot study aims to prospectively determine the effectiveness of EUS-FNB regarding adequacy of tissue for IHC staining, diagnostic rate and the avoidance rate of diagnostic laparoscopy or percutaneous biopsy in patients with these lesions.
Cholangiocarcinoma is a malignant neoplasm originating from the biliary epithelium. Its incidence is highest in Southeast Asia, especially in Thailand. Mucinous intrahepatic cholangiocarcinoma (mucinous iCCA), characterized by an abundant extracellular mucin pool accounting for at least 50% of total tumor volume, is an extremely rare variant of such malignancy and is notorious for rapid progression and dismal prognosis.
View Article and Find Full Text PDFBackground And Objectives: Most of the available data on pancreatic cancer are from Western countries. The aim was to characterize pancreatic cancer in Asian patients and to compare it with pancreatic cancer in Caucasians.
Materials And Methods: Inpatients with histologically proven pancreatic cancer were retrospectively recruited at King Chulalongkorn Memorial Hospital from January 2005 to December 2011.
Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg).
Asian Pac J Cancer Prev
September 2014
Background: A missense mutation in exon 7 (R249S) of the p53 tumor suppressor gene is characteristic of aflatoxin B1 (AFB1) exposure. AFB1 is believed to have a synergistic effect on hepatitis virus B (HBV) carcinogenesis. However, results of studies comparing R249S prevalence among patients are conflicting.
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