APH(3')-Ie, an aminoglycoside-modifying enzyme discovered in a rabbit-derived isolate.

Background: Aminoglycoside-modifying enzymes (AMEs) play an essential role in bacterial resistance to aminoglycoside antimicrobials. With the development of sequencing techniques, more bacterial genomes have been sequenced, which has aided in the discovery of an increasing number of novel resistance mechanisms.

Methods: The bacterial species was identified by 16S rRNA gene homology and average nucleotide identity (ANI) analyses.

Identification and characterization of a novel 6'-N-aminoglycoside acetyltransferase AAC(6')-Va from a clinical isolate of .

Background: species have been identified as agents responsible for various diseases in both humans and animals. Multidrug-resistant strains pose a significant public health threat due to their emergence and spread in clinical settings and the environment. The aim of this study was to determine a novel resistance mechanism against aminoglycoside antimicrobials in a clinical isolate.

Identification and characterization of a novel β-lactamase gene, , from .

Background: is a genus of gram-negative bacteria that can act as opportunistic pathogens. Recent studies have revealed that some species of show inherent resistance to β-lactams, but the resistance mechanisms of have rarely been reported.

Method: The bacterium was isolated using standard laboratory procedures.

Identification and characterization of a novel chromosomal aminoglycoside 3'--phosphotransferase, APH(3')-Id, from DW18 isolated from the sewage of an animal farm.

Background: Aminoglycosides, as important clinical antimicrobials, are used as second-line drugs for treating multidrug-resistant tuberculosis or combined with β-lactam drugs for treating severe infections such as sepsis. Aminoglycoside-modifying enzyme (AME) is the most important mechanism of aminoglycoside resistance and deserves more attention.

Methods: The bacterium DW18 was isolated from the sewage of an animal farm using the conventional method.

, a novel AmpC gene identified from a isolate.

Background: species of the family are well-known plant pathogens and animal and human conditional pathogens. Due to the widespread and continuous use of antimicrobials, multidrug-resistant strains continue to emerge, making clinical treatment difficult; therefore, there is an increasing need to clarify the mechanisms of drug resistance.

Methods: A rabbit anal fecal sample was collected by a swab and the streak plate method was used to isolate single colonies.