pFAK-Y397 overexpression as both a prognostic and a predictive biomarker for patients with metastatic osteosarcoma.

Focal adhesion kinase (FAK) is important for tumor cell survival and metastasis in various cancers. However, its expression and prognostic value in patients with metastatic osteosarcoma remain unknown. We investigated the expression of FAK and its phosphorylated form (pFAK-Y397) in osteosarcoma tissues from 53 patients by immunohistochemistry and evaluated their correlations with clinicopathologic characteristics and outcomes.

Comparative outcome of Thai pediatric osteosarcoma treated with two protocols: the role of high-dose methotrexate (HDMTX) in a single institute experience.

Background: High-dose methotrexate (HD-MTX) is recognized as an efficient component of therapy against pediatric osteosarcoma in combination with other drugs such as cisplatin (CDP), carboplatin (CBDCA), doxorubicin (ADM), etoposide (VP-16) and ifosfamide (IFO).

Objectives: To demonstrate the feasibility and effectiveness of the HD-MTX/CDP/DOX/VP-16/IFO [MTX(+)] protocol comparable to CDP/ADM/CBDCA/IFO [MTX(-)] for treating childhood osteosarcoma at Ramathibodi Hospital (1999-2014).

Materials And Methods: A retrospective analysis was conducted of osteosarcoma patients aged less than 18 years treated with two chemotherapeutic regimens between 1999 and 2014.

Age and survival of cervical cancer patients with bone metastasis.

Background: To determine survival times of cervical cancer patients with bone metastasis related to the effect of age at the time of cervical cancer diagnosis, we performed the retrospectively analytical study.

Methods: A total of 68 cervical cancer patients with bone metastasis were treated at a single hospital, during January 1998 to December 2010. Fifty-two medical records were identified and collected, the remaining sixteen medical records were not found.

Parosteal ossifying lipoma of the fibula: a case report with contrast-enhanced MR study and a review of the literature.

This report describes a rare case of parosteal ossifying lipoma of the fibula. Very few reports have described the magnetic resonance (MR) imaging features with gadolinium enhancement of this neoplasm. In this case, low-signal-intensity strands within the lipomatous mass on T1-weighted image with varying degrees of enhancement were detected.

Emergency ultrasonography in patients with clinically suspected soft tissue infection of the legs.

Introduction: We aimed to retrospectively review the ultrasonography (US) findings of patients with clinically suspected soft tissue infection of the legs and to determine whether there is a correlation between US diagnosis and further clinical management.

Methods: We reviewed the US findings of consecutive patients with clinically suspected soft tissue infection of the legs who were referred for emergency US during a consecutive two-year period. The indications for US were recorded and the findings evaluated.

Dynamic contrasted MR imaging in differentiation of recurrent malignant soft tissue tumor from posttreatment changes.

Objective: To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in term of differentiation recurrent malignant soft tissue tumor (MSTT) from post-treatment changes.

Material And Method: DCE-MRI was performed in consecutive patients in two-year periods to differentiate recurrent MSTT from post-treatment (surgery radiotherapy chemotherapy) changes. The steepest slope (SS) ratio between the artery and the lesion, sensitivity, and specificity were calculated.

Comparison of outcomes for patients with cervical cancer who developed bone metastasis after the primary treatment with concurrent chemoradiation versus radiation therapy alone.

Objectives: The aims of this study were to retrospectively compare outcomes for patients with cervical cancer who developed bone metastasis later after the primary treatment at the time of diagnosis of cervical cancer with concurrent chemoradiation (CCRT) to radiation therapy alone (RT).

Methods: We retrospectively analyzed the patients with cervical cancer during the period from January 1998 to December 2007. Of these, 11 patients who received CCRT and 24 patients who received RT went on to develop bone metastasis.

MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma.

Introduction: This study aimed to retrospectively review the magnetic resonance (MR) imaging features of the lipomatous tumour in order to differentiate between lipoma and liposarcoma.

Methods: The MR images of 38 patients (24 female and 14 male with a mean age 48 years) in a consecutive five-year period, who had histologically verified lipoma (n is 29) and liposarcoma (n is 9), were retrospectively reviewed. The images were assessed for the number, site, size and margin of the lesions, as well as the signal intensity (homogenous, bright signal on T1-weighted [T1W] image, bright signal suppressed on T1W with fat-suppression image, bright signal on T2-weighted with fat-suppression image), the internal architecture (thin/thick septum, cystic change), the effect on the surrounding tissue (oedema, neurovascular involvement) and the enhancement pattern.

Bone metastasis in cervical cancer patients over a 10-year period.

Introduction: Cervical cancer is the major cancer burden in developing countries. Bone is the third most common site of distant metastasis after the lungs and liver. Therefore, the aims of this study were to find the incidence and clinical characteristics of bone metastasis in our hospital.