Effects of Circuit Aerobic Step Exercise Program on Musculoskeletal for Prevention of Falling and Enhancement of Postural Balance in Postmenopausal Women.

Objective: The objective of this research was to develop a circuit aerobic step exercise program and to examine the effects of the circuit aerobic step exercise program on bone formation, bone resorption, muscle strength and body balance of the postmenopausal females.

Material And Method: The samples consisted of 52 female participants from Chulalongkorn University, aged between 45-55 years old. The subjects were divided into two groups: 26 females in the circuit aerobic step exercise group (CASE) and 26 females in the control group (CON) by the simple random sampling method.

A Comparison between the Effects of Aerobic Dance Training on Mini-Trampoline and Hard Wooden Surface on Bone Resorption, Health-Related Physical Fitness, Balance, and Foot Plantar Pressure in Thai Working Women.

Objective: To compare the effects of aerobic dance training on mini-trampoline and hard wooden surface on bone resorption, health-related physical fitness, balance, and foot plantar pressure in Thai working women.

Material And Method: Sixty-three volunteered females aged 35-45 years old participated in the study and were divided into 3 groups: A) aerobic dance on mini-trampoline (21 females), B) aerobic dance on hard wooden surface (21 females), and C) control group (21 females). All subjects in the aerobic dance groups wore heart rate monitors during exercise.

Effects of Aerobic Step Combined with Resistance Training on Biochemical Bone Markers, Health-Related Physical Fitness and Balance in Working Women.

The objectives of this research were to develop an aerobic step combined with resistance training exercise program, and to compare the effects of A) aerobic step exercise training (STE), B) resistance aerobic exercise training (RES), C) a combined aerobic step with resistance exercise training (COM) on the health-related fitness, balance, and biochemical bone markers. Sixty participants were working female volunteers at the age of 35-45. They were divided into 4 groups by simple random sampling method.

Effects of Short-Term Vitamin D Supplementation on Musculoskeletal and Body Balance for Prevention of Falling in Postmenopausal Women.

Objective: The objective of this research was to examine the effects of the short-duration (4 weeks) vitamin D supplementation on biochemical bone markers, muscle strength and balance of the postmenopausal females.

Material And Method: The participants consisted of 52 female participants from Chulalongkorn University, aged between 45-55 years old. They were divided into two groups: 26 females in the vitamin D supplementation (VID) and 26 females in the control group (CON) by the simple random sampling method.

The Intriguing Correlation between Undercarboxylated Osteocalcin and Vitamin D.

Osteocalcin (OC) or bone Gla protein (BGP), a bone specific protein, is one of circulating biomarkers that can be used to determine the quality of bone tissues. It is synthesized by the osteoblast and the odontocyte. The process of OC production requires two types ofvitamin: vitamin D and vitamin K.

Study of the Safe Dosage of Ergocalciferol.

Vitamin D2 or ergocalciferol can replace vitamin D3, but its dosage must be a higher international unit: one unit of vitamin D3 is equal to 4 units ofvitamin D2. A proper interval of administration should take 200,000 IUper day. The 123 cases enrolled for study, every case had blood levels of 25 (OH) D and blood calcium checked before intake of vitamin D2 followed by a second check after 2 months.

Estimation of Osteoblastic Functions by Biological Bone Markers.

The purpose of this study is to identify the lowest value ofNMID osteocalcin and PINP when CTx is below or equal to 0.10 ng/ml at which neither bone formation nor bone resorption occurs. This may be harmful to bone texture.

Efficacy of Bisphosphonates Evaluated by Biological Bone Markers.

This research aimed to study the benefits of bone markers on bisphosphonate, alendronate plus (vitamin D3 2800IU) administered once a week as a model especially regarding BetacrossLap, CTx. The enrolled cases were 306 (female = 282, male = 24) with high CTx (≥ 0.300 ng/ml).

Bone markers in the healthy Thai people.

Osteoporosis is a systemic skeletal disease characterized by low bone mineral density (BMD) and micro-architectural deterioration of the bone tissues resulting in bone fragility and susceptibility to fracture. It is caused by the decrease of bone formation and the increase of bone resorption. Both bone formation and resorption can be examined by the circulating biomolecules.

Correlation between the circulating bone markers and vitamin D in the healthy Thai people.

There are several circulating bone markers that are useful for physicians in determining the bone quality. The markers are composed of N-terminal propeptide of type I collagen (PINP) which determines the bone formation, undercarboxylated osteocalcin (UcOC) and N-mid fragment of osteocalcin (N-MID) which determines the bone remodeling, C-telopeptide of type I collagen (betaPCTx) or betacrosslap (betaCTx), pyridinoline (PYD) and deoxypyridinoline (DPD) which determines the bone resorption. The vitamin named vitamin D (VitD) also affects the bone property.

The reality of osteocalcin as a marker of vitamin K2.

The present study showed the correlation between undercarboxylated osteocalcin and vitamin D had a role in production of the undercarboxylated osteocalcin, when the amount of vitamin D 25 (OH) D, (below 30 ng/ml) was decreased, the linear correlation (r) between the vitamin D and undercarboxylated osteocalcin were also decreased r = 0.032 when the level of vitamin D was risen, the linear correlation was 0.274,unfortunately the study-population had little group of the normal level of vitamin D due to most of them were vitamin D insufficiency so the authors could not show the more value of 'r'.

Osteoblastic functions: a lesson from biochemical bone markers.

The present study showed the lowest values of bone markers from osteoblast, NMID osteocalcin, 10.81 +/- 3.9 ng/ ml and PINP 15.

Study of validity of pyridinoline and correlation of pyridinoline and beta crosslap in postmenopausal women.

This research studied the validity and correlation of beta-CTx (Betacrosslap) and Pyridinoline (PYD) in 71 cases of postmenopausal Thai women who attended at the osteoporosis clinic. The validity consisted of sensitivity, specificity and accuracy of PYD. They were 53.

A study of correlation of osteoblasts from peripheral blood with related bone turnover markers.

The bone remodeling process called osteoblasts has an important role in bone formation working together with osteoclasts of which the cells are responsible for bone resorption. In addition, these bone turnover markers are used to follow-up the conditions of bone remodeling in the patients. Recently, osteoblastic lineage cells have been found that they exist in the human peripheral blood.

Calcium supplement: humanity's double-edged sword.

The principle aim of the present study is to investigate the dark side of calcium, pollutions in calcium preparation especially lead (Pb), mercury (Hg) and cadmium (Cd). The collected samples were the different calcium salts in the market and 18 preparations which were classified into 3 groups: Calcium carbonate salts, Chelated calcium and natural-raw calcium. All samples were analyzed for lead, cadmium and mercury by inductively Coupled Plasma Mass Spectrometry (ICP-MS) technique, in house method based on AOAC (2005) 999.

The bone turnover markers in healthy Thai adults as the standard values.

The present study of the bone markers in the healthy Thai females and males enrolled 588 females and 53 males with age range from 25 to 42 years. The potential modification of variations was controlled. The bone resorptive markers, betaCTx, of females and males were 0.

The action of Strontium ranelate: myth or reality.

The present study aimed to show whether the Strontium ranelate was the dual action possessing either antiresorptive or formative properties. This retrograded study included 56 postmenopausal women using the biological bone turnover markers as an evaluation. The antiresorptive property described by the mean value of Beta-crossLap or bCTx before taking 2 grams of Strontium ranelate per day was 0.

Experience of application: blood screening and bone turnover markers for prevention of unwanted effects and early outcomes of teriparatide.

This clinical study aimed to provide awareness of the teriparatide injection and also prevention of unwanted events. The 72 cases aged between 52-69 with the inclusion criteria: back pain proved by the x-ray with one or more collapsed spines, no underlying diseases and no history of bone tumor, hyperparathyroid, hypercalcemia. The blood screening for renal, liver profiles, uric acid, mineral profile and bone turnover markers (bCTx, PINP) are used as 6-month monitor.

Effects of the circuit box jumping on bone resorption, health-related to physical fitness and balance in the premenopausal women.

The purpose of this research is to develop a circuit box jumping exercise program and to examine the effects of the circuit box jumping exercise program on bone formation, bone resorption, health related to physical fitness and balance of the premenopausal females. The samples consisted of 57 female volunteers from Chulalongkorn University, aged between 35-45. The subjects were divided into two groups: 28 females in the experimental group and 29 females in the control group by the simple random sampling method.

Recommended dose of alfacacidol for osteoporosis.

The present study aims to investigate a proper dose of alfacalcidol by using the parathyroid level as a marker due to the end product of alfacalcidol is calcitriol which has a property of suppression secretion of parathyroid glands. The research enrolled 259 volunteers which were divided into 2 groups. Each group took the elemental calcium 800 milligram plus alfacalcidol at the different doses.

Parathyroid hormone enhances osteoblast differentiation from human skin derived precursor cells in vitro.

Parathyroid hormone (PTH), a new effective treatment for osteoporosis patients which promotes the anabolic effect in vivo, can enhance the differentiation of osteoblasts derived from the human skin-derived precursor cells (hSKPs) in vitro culture. This research investigated the effects of PTH by studying the gene expressions and other markers of osteoblast differentiation along with the induction of hSKPs to osteoblast in two experiment groups, i.e.

Safety and antisorptive power of Ibandronate applied in the real-life setting.

This study involved 78 participants taking 150 mg of Ibandronate once a month for the investigation of the drug efficacy and safety. Ibandronate had a strong antiresorptive action that decreased 67.9 per cent of bone resorption.

Highly recommended dose of MK4 for osteoporosis.

The recommended dose of Menatretenone is 45 mg three times a day; however the compliant in daily practice is not convenient. This study shows the twice dose per day is inferior to the recommended dose. This study used the level of Gla protein in osteocalcin as a parameter for the comparison.

The role of vitamin K2 on osteoblastic functions by using stem cell model.

Vitamin K2 (MK4) functions were investigated by using the induced skin cell into osteoblast compared with the control media. The real time PCR measured gene expression in both cultures at the fourth, seventh, fourteenth, twenty first, twenty eighth, thirty fifth and forty second days of culture. The gene expressions of osteocalcin, osteonectin, osteopontin, bone sialoprotein, CBFA1, Interleukin-6, Estrogen receptors and collagen type) were monitored by real time PCR.