Publications by authors named "Narmadha P Reddy"
Retrospective study of comparison of clinical severity and outcome of hospitalised COVID-19 patients during the first and second waves of the pandemic in India.
BMJ Open
November 2022
Article Synopsis
- This study compared the clinical severity and outcomes of hospitalized COVID-19 patients in India during the first wave (April-Dec 2020) and the second wave (April-May 2021).
- Results showed that the second wave had a significantly higher proportion of critical illness, increased need for oxygen and other treatments, and higher mortality rates (19.2% compared to 9.3%).
- Key factors associated with higher mortality included being over 60, having high D-dimer levels, requiring supplemental oxygen, and being hospitalized during the second wave.
Impact of prior vaccination with Covishield and Covaxin® on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study.
Vaccine
March 2022
Background: COVID-19 vaccines were authorised for emergency use to mitigate the impact of the pandemic. This study evaluated the effect of prior vaccination with either Oxford Astra Zeneca's Covishield™ or Bharath Biotech's Covaxin® on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in India.
Methodology: In this cohort study comprising of RT-PCR confirmed symptomatic COVID-19 patients presenting during April and May 2021, the effect of prior vaccination on mortality (primary outcome), need for hospitalization, oxygen therapy, non-invasive ventilation (NIV) and intensive care unit (ICU) admission were assessed and expressed as risk ratio (RR) with 95% confidence intervals (CI).